B6-hMADCAM1
Product Type
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Genotype
Sex
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Basic Information
Model Name
B6-hMADCAM1
Product ID
C001816
Gene Name
Background
C57BL/6NCya
Gene Alias
MACAM1
Classification
Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hMADCAM1 mice (Catalog C001816) were purchased from Cyagen.”
Strain Description
The B6-hMADCAM1 mouse is a humanized model, constructed by replacing the sequences from exon 1 to a partial intron 4 of mouse Madcam1 with the sequences from the ATG start codon to the TGA stop codon of the human MADCAM1 gene, and the 3' UTR of mouse Madcam1-rBG pA cassette is inserted downstream of the TGA stop codon. B6-hMADCAM1 mice can be used for research into the pathogenesis of inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis, primary sclerosing cholangitis, type 1 diabetes, and certain cancers. They are also useful for the screening, development, and safety evaluation of MADCAM1-targeted drugs.
Application Area
MADCAM1-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis
Research on the primary sclerosing cholangitis
Research on type 1 diabetes
Research on certain cancers
Validation Data