B6-hCD28
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hCD28
Product ID
C001817
Gene Name
Background
C57BL/6NCya
Gene Alias
Tp44
Classification
Immune Target Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hCD28 mice (Catalog C001817) were purchased from Cyagen.”
Strain Description
The B6-hCD28 mouse is a humanized model, constructed by replacing the mouse Cd28 endogenous extracellular domain (aa.20~150) with the human CD28 extracellular domain (aa.19~152). The murine signal peptide (aa.1~19) and aa.151~218 are preserved. B6-hCD28 mice can be used for research into the pathogenesis of autoimmune disorders such as rheumatoid arthritis, Sjogren's syndrome, and systemic sclerosis, as well as in transplant rejection, certain cancers (e.g., T-cell lymphomas, acute myeloid leukemia, breast cancer), and chronic infections like HIV. They are also useful for the screening, development, and safety evaluation of CD28-targeted drugs.
Application Area
CD28-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of autoimmune disorders such as rheumatoid arthritis, Sjogren's syndrome, and systemic sclerosis
Research on the transplant rejection
Research on the pathological mechanisms and therapeutic approaches of certain cancers
Research on the pathological mechanisms and therapeutic approaches of chronic infections like HIV
Validation Data