B6-hTTN
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hTTN
Product ID
C001819
Gene Name
Background
C57BL/6NCya
Gene Alias
TMD; CMH9; CMD1G; CMPD4; CMYP5; EOMFC; HMERF; MYLK5; SALMY; LGMD2J; LGMDR10
Classification
Full-Gene Humanized Models,Other Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hTTN mice (Catalog C001819) were purchased from Cyagen.”
Strain Description
The B6-hTTN mouse is a humanized model constructed via gene-editing technology. The sequence from the ATG start codon to the TAA stop codon of mouse Ttn will be replaced with the sequence from the ATG start codon to the TAA stop codon of human TTN. B6-hTTN mice can be used to study the pathogenesis of hereditary muscle diseases such as familial dilated cardiomyopathy (DCM), early-onset myopathy, and muscular dystrophy, as well as for the screening, development, and safety evaluation of TTN-targeted drugs.
Application Area
TTN-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of genetic muscle diseases such as familial dilated cardiomyopathy (DCM), early-onset myopathy, and muscular dystrophy
Validation Data