The Rpgr KO mouse is a gene knockout model created using gene-editing techniques to knock out the coding sequence of the Rpgr gene (the homolog of the human RPGR gene) in mice. This model can be used to study the pathogenic mechanisms of retinal diseases like X-linked retinitis pigmentosa (XLRP) and X-linked cone-rod dystrophy (CORDX1), providing a research basis for developing related therapeutic interventions.