B6-hOSMR
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-hOSMR
Product ID
C001841
Gene Name
Background
C57BL/6NCya
Gene Alias
OSMRB; PLCA1; IL-31RB; OSMRbeta; IL-31R-beta
Classification
Tumor Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
--
Document
Note: When using this mouse strain in a publication, please cite “B6-hOSMR mice (Catalog C001841) were purchased from Cyagen.”
Strain Description
B6-hOSMR mouse is a humanized model constructed by replacing the coding sequences of exon 2 and partial intron 2 sequence of the murine Osmr gene with the Kozak-OSMR chimeric CDS-3'UTR of mouse Osmr-WPRE-BGH pA expression cassette. This model is applicable to mechanistic research on inflammatory diseases (e.g., rheumatoid arthritis, atopic dermatitis), cancers (cervical squamous cell carcinoma, lung adenocarcinoma, pancreatic cancer), cardiovascular diseases (e.g., atherosclerosis), liver diseases (e.g., fibrosis), and hematopoietic and bone marrow-related disorders. It also supports the screening, development, and safety evaluation of OSMR-targeted drugs.
Application Area
Screening, development, and preclinical evaluation of OSMR-targeted drugs
Research on the pathological mechanisms and therapeutic approaches of inflammatory diseases, such as rheumatoid arthritis (RA), atopic dermatitis (AD), and inflammatory bowel disease (IBD)
Research on the pathological mechanisms and therapeutic approaches of cancers, including cervical squamous cell carcinoma, lung adenocarcinoma, and pancreatic cancer
Research on cardiovascular diseases (e.g., atherosclerosis)
Research on liver diseases (e.g., fibrosis)
Research on hematopoietic and bone marrow-related disorders
Validation Data