B6-huKLKB1
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Basic Information
Model Name
B6-huKLKB1
Product ID
C001845
Gene Name
Background
C57BL/6JCya
Gene Alias
PKK; PPK; KLK3; PKKD
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-huKLKB1 mice (Catalog C001845) were purchased from Cyagen.”
Strain Description
The B6-huKLKB1 mice are a humanized model constructed through gene editing technology, in which the mouse Klkb1 endogenous domain (aa.20~638) is replaced with the human KLKB1 domain (aa.20~638). The murine signal peptide (aa.1~19) is kept. This model can be used for the study of the pathological mechanisms and treatment methods of prekallikrein deficiency and hereditary angioedema. It can also be applied to the development of KLKB1-targeted drugs.
Application Area
Screening, development, and evaluation of KLKB1-targeted drugs
Research on the pathological mechanisms and treatment methods of prekallikrein deficiency and hereditary angioedema (HAE)
Validation Data