B6-hMRGPRX2
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Basic Information
Model Name
B6-hMRGPRX2
Product ID
C001846
Gene Name
Background
C57BL/6NCya
Gene Alias
MGRG3; MRGX2
Classification
Other Target Humanized Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hMRGPRX2 mice (Catalog C001846) were purchased from Cyagen.”
Strain Description
The B6-hMRGPRX2 mouse is a humanized model, constructed by replacing the sequences from exon 1 to partial intron 1 of mouse Mrgprx2 with the Kozak-human MRGPRX2 CDS-3'UTR of mouse Mrgprx2-WPRE-BGH pA cassette. B6-hMRGPRX2 mice can be used for research into the pathogenesis of various inflammatory and pruritic diseases, including chronic spontaneous urticaria and atopic dermatitis. They are also useful for the development of MRGPRX2-targeted drugs.
Application Area
MRGPRX2-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of various inflammatory and pruritic diseases, including chronic spontaneous urticaria and atopic dermatitis
Validation Data