B6-huIL22
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-huIL22
Product ID
C001847
Gene Name
Background
C57BL/6NCya
Gene Alias
TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
Classification
Cytokine Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-huIL22 mice (Catalog C001847) were purchased from Cyagen.”
Strain Description
The B6-huIL22 mouse is a humanized model constructed via gene-editing technology. The sequence from the ATG start codon to the TGA stop codon of mouse Il22 will be replaced with the sequence from the ATG start codon to the TGA stop codon of human IL22. B6-huIL22 mice can be used for research into the pathogenesis of autoimmune disorders like psoriasis, rheumatoid arthritis (RA), and inflammatory bowel disease (IBD), as well as some cancers and infections, and for the screening, development, and safety evaluation of IL22-targeted drugs.
Application Area
IL22-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of certain cancers
Research on the pathological mechanisms and therapeutic approaches of autoimmune disorders, such as psoriasis, rheumatoid arthritis (RA), and inflammatory bowel disease (IBD)
Research on infections
Validation Data