B6-huIL22 Mouse
Product Name
B6-huIL22 Mouse
Product ID
C001847
Strain Name
C57BL/6NCya-Il22tm1(hIL22)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “B6-huIL22 Mouse (Catalog C001847) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
IL22
Gene Alias
TIFa, IL-21, IL-22, ILTIF, IL-TIF, IL-D110, zcyto18, TIFIL-23
NCBI ID
Chromosome
Chr 12 (Human)
MGI ID
Datasheet
Strain Description
The IL22 gene encodes the protein interleukin-22, a cytokine of the IL-10 family. This gene is primarily expressed in immune cells, such as T helper 17 (Th17) cells, Th22 cells, and innate lymphoid cells (ILCs), which then produce and secrete the IL-22 protein [1]. Unlike most cytokines, which primarily act on immune cells, IL-22's primary targets are non-hematopoietic cells, specifically the epithelial and stromal cells that form the body's barrier tissues. IL-22 receptor is most notably found in tissues such as the skin, lungs, gastrointestinal tract, liver, and pancreas. The protein's dual function includes promoting antimicrobial defense and tissue repair by inducing proliferation and inhibiting apoptosis in these epithelial cells [2]. However, its dysregulation is associated with both inflammatory and protective roles in a variety of diseases. High levels of IL-22 are linked to autoimmune conditions like psoriasis, rheumatoid arthritis (RA), and inflammatory bowel disease (IBD), as well as some cancers, while in other contexts, it can be protective, aiding in the recovery from infections and tissue damage [3].
The B6-huIL22 mouse is a humanized model constructed via gene-editing technology. The sequence from the ATG start codon to the TGA stop codon of mouse Il22 will be replaced with the sequence from the ATG start codon to the TGA stop codon of human IL22. B6-huIL22 mice can be used for research into the pathogenesis of autoimmune disorders like psoriasis, rheumatoid arthritis (RA), and inflammatory bowel disease (IBD), as well as some cancers and infections, and for the screening, development, and safety evaluation of IL22-targeted drugs.
Reference
Fard NA, Azizi G, Mirshafiey A. The Potential Role of T Helper Cell 22 and IL-22 in Immunopathogenesis of Multiple Sclerosis. Innov Clin Neurosci. 2016 Aug 1;13(7-8):30-6.
Zhu C, Chen J, Yan Z, Wang F, Sun Z, Liu Z, Li Y, Chen X, Bao Z, Li Q, Chen Z. IL-22 Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Epithelial Cell Apoptosis Associated with STAT3 Signalling. J Inflamm Res. 2025 Apr 21;18:5383-5398.
Sonnenberg GF, Fouser LA, Artis D. Functional biology of the IL-22-IL-22R pathway in regulating immunity and inflammation at barrier surfaces. Adv Immunol. 2010;107:1-29.
Strain Strategy
The sequences from the ATG start codon to the TGA stop codon of the endogenous mouse Il22 gene will be replaced with the sequences from the ATG start codon to the TGA stop codon of the human IL22 gene.
Figure 1. Gene editing strategy of B6-huIL22 mice.
Application Area
IL22-targeted drug screening, development, and evaluation;
Research on the pathological mechanisms and therapeutic approaches of certain cancers;
Research on the pathological mechanisms and therapeutic approaches of autoimmune disorders, such as psoriasis, rheumatoid arthritis (RA), and inflammatory bowel disease (IBD);
Research on infections.
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