B6-huAPRIL (huTNFSF13)
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Basic Information
Model Name
B6-huAPRIL (huTNFSF13)
Product ID
C001852
Gene Name
Background
C57BL/6NCya
Gene Alias
APRIL; CD256; TALL2; ZTNF2; TALL-2; TNLG7B; TRDL-1; UNQ383/PRO715
Classification
Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-huAPRIL (huTNFSF13) mice (Catalog C001852) were purchased from Cyagen.”
Strain Description
The B6-huAPRIL (huTNFSF13) mouse is a humanized model constructed via gene-editing technology. The sequence from the ATG start codon to the TGA stop codon of mouse Tnfsf13 is replaced with the sequence from the ATG start codon to the TGA stop codon of human TNFSF13. B6-huAPRIL (huTNFSF13) mice can be used for research into the pathogenesis of autoimmune disorders like rheumatoid arthritis (RA), IgA nephropathy, and systemic lupus erythematosus (SLE), as well as some cancers, and for the development of TNFSF13-targeted drugs.
Application Area
TNFSF13-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of certain cancers
Research on the pathological mechanisms and therapeutic approaches of autoimmune disorders, such as rheumatoid arthritis (RA), IgA nephropathy, and systemic lupus erythematosus (SLE)
Validation Data