B6-huDLL3
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-huDLL3
Product ID
C001854
Gene Name
Background
C57BL/6NCya
Gene Alias
SCDO1
Classification
Tumor Target Humanized Models,Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
--
Document
Note: When using this mouse strain in a publication, please cite “B6-huDLL3 mice (Catalog C001854) were purchased from Cyagen.”
Strain Description
The B6-huDLL3 mice are a humanized model constructed through gene editing technology, in which the mouse Dll3 endogenous extracellular domain (aa.25~490) is replaced with the human DLL3 extracellular domain (aa.27~492). The murine signal peptide and transmembrane-cytoplasmic region (aa.1~24, aa.491~585) are preserved. This model can be used for the study of the pathological mechanisms and treatment methods of DLL3-highly-expressed malignant tumors and Spondylocostal dysostosis type 1. It can also be applied to the development of DLL3-targeted drugs.
Application Area
Screening, development, and evaluation of DLL3-targeted drugs
Research on the pathological mechanisms and treatment methods of Spondylocostal dysostosis type 1
Research on the pathological mechanisms and treatment methods of DLL3-highly-expressed malignant tumors
Validation Data