huCD98HC(SLC3A2) Mouse
Product Name
huCD98HC(SLC3A2) Mouse
Product ID
C001857
Strain Name
C57BL/6NCya-Slc3a2tm1(hSLC3A2)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “huCD98HC(SLC3A2) Mouse (Catalog C001857) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
SLC3A2
Gene Alias
4F2, CD98, MDU1, 4F2HC, 4T2HC, NACAE, CD98HC
NCBI ID
Chromosome
Chr 11 (Human)
MGI ID
Datasheet
Strain Description
The SLC3A2 gene (Solute Carrier Family 3 Member 2), also known as CD98hc or 4F2hc, is ubiquitously expressed across many tissues and is often upregulated in various cancers, including lung, breast, and colorectal cancer. It encodes the cell-surface, transmembrane heavy chain of a heterodimeric amino acid transporter complex, which is covalently bound via disulfide bonds to a light chain from the SLC7A family (e.g., SLC7A5/LAT1 or SLC7A11/xCT). The primary function of the encoded protein is to act as a chaperone necessary for the light chain's proper plasma membrane localization and stability. The resulting functional complex transports specific essential amino acids; for instance, the SLC3A2/SLC7A5 dimer transports L-type neutral amino acids, while the SLC3A2/SLC7A7 dimer transports dibasic amino acids. This nutrient uptake is crucial for cell growth and metabolic reprogramming [1]. Beyond its transport role, SLC3A2 independently modulates integrin-dependent signaling pathways, affecting processes like cell spreading, adhesion, migration, and proliferation, which links it closely to cancer progression [2]. Cellular tissues with notable expression include trophoblasts (placenta), kidney proximal tubular cells, glandular cells (breast), Sertoli cells (testis), and various immune cells. SLC3A2 is primarily associated with cancer, where it acts as an oncoprotein and prognostic marker. It is also involved in specific cell death pathways like disulfidptosis [3]. Genetic associations have also been suggested between the SLC3A2 locus and conditions like schizophrenia, vitiligo, and Ulcerative Colitis, highlighting its broader role in cellular homeostasis [4].
huCD98HC(SLC3A2) mouse is a humanized model generated using gene editing technology, in which the mouse Slc3a2 endogenous extracellular domain is replaced with the human SLC3A2 extracellular domain. The murine cytoplasmic domain and transmembrane domain are preserved. This model can be used for research related to cancer, amino acid transport and metabolic intervention, immune regulation and autoimmunity, as well as the development of SLC3A2-targeted drugs.
Reference
Xia P, Dubrovska A. CD98 heavy chain as a prognostic biomarker and target for cancer treatment. Front Oncol. 2023 Sep 26;13:1251100.
Li Z, Chen S, He X, Gong S, Sun L, Weng L. SLC3A2 promotes tumor-associated macrophage polarization through metabolic reprogramming in lung cancer. Cancer Sci. 2023 Jun;114(6):2306-2317.
Zhang X, Lin Y, Shi L, Zhai A, Wu C, Zhu QY. Disulfidptosis-related gene SLC3A2: a novel prognostic biomarker in nasopharyngeal carcinoma and head and neck squamous cell carcinoma. Front Oncol. 2025 Jan 24;15:1451034.
Yang QQ, Guo JA, Zhang K, Li SH, Xia WY, Wang DX, Xie LS, Wang JM, Wu QF. Disulfidptosis and Its Hub Gene Slc3a2 Involved in Ulcerative Colitis Pathogenesis, Disease Progression, and Patient Responses to Biologic Therapies. Int J Mol Sci. 2024 Dec 17;25(24):13506.
Strain Strategy
The mouse Slc3a2 endogenous extracellular domain was replaced with the human SLC3A2 extracellular domain. The murine cytoplasmic domain and transmembrane domain were preserved.
Figure 1. Gene editing strategy of huCD98HC(SLC3A2) mice.
Application Area
Screening, development, and preclinical evaluation of CD98HC(SLC3A2)-targeted drugs;
Research on the pathological mechanisms and therapeutic approaches of various cancers;
Research on amino acid transport mechanisms and metabolic diseases;
Research on immune regulation and autoimmunity.
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