B6-hGIPR
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hGIPR
Product ID
C001858
Gene Name
Background
C57BL/6NCya
Gene Alias
PGQTL2
Classification
Metabolic Target Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
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Datasheet
Note: When using this mouse strain in a publication, please cite “B6-hGIPR mice (Catalog C001858) were purchased from Cyagen.”
Strain Description
B6-hGIPR mouse is a humanized model generated using gene editing technology, in which the Exon 3~14 of the coding sequence (CDS) encoding the human GIPR protein and the 3'UTR of mouse Gipr gene are integrated into a specific site within the mouse Gipr gene, while retaining the endogenous gene sequence encoding the murine signal peptide (aa.1~18) and aa.19. This model can be used for studying the pathological mechanisms and therapeutic approaches of metabolic and inflammatory diseases and potentially selected malignancies, as well as for the development of GIPR-targeted drugs.
Application Area
GIPR-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of metabolic and inflammatory diseases and potentially selected malignancies
Validation Data