huACVR2B Mouse
Product Name
huACVR2B Mouse
Product ID
C001904
Strain Name
C57BL/6NCya-Acvr2btm1(hACVR2B)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “huACVR2B Mouse (Catalog C001904) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
ACVR2B
Gene Alias
HTX4, ACTRIIB, ActR-IIB
NCBI ID
Chromosome
Chr 3 (Human)
MGI ID
Datasheet
Strain Description
The ACVR2B gene encodes the activin A type IIB receptor, a transmembrane protein belonging to the transforming growth factor-β (TGF-β) superfamily. It is widely expressed in various human tissues, with particularly critical expression levels in tissues closely related to physiological functions, such as muscle, bone, and gonads. The protein encoded by ACVR2B is a type II serine/threonine kinase receptor, consisting of three core domains: an extracellular ligand-binding domain, a transmembrane domain, and a cytoplasmic kinase domain. It can initiate signal transduction by binding to ligands like activin and myostatin. Functionally, ACVR2B is a key molecule regulating multiple physiological processes. In muscle, it inhibits muscle growth by mediating myostatin signaling and serves as a core target for the regulation of muscle atrophy and growth [1]. In the reproductive system, it participates in processes such as folliculogenesis and spermatogenesis by regulating gonadal hormone secretion [2-3]. Additionally, it is involved in energy metabolism, influencing fat accumulation and the development of metabolic syndrome. Abnormal ACVR2B function or signal imbalance is associated with various diseases: in cancer cachexia, overactivation of its mediated signaling pathways accelerates muscle breakdown [4]. In metabolic syndrome and obesity, abnormal expression of this gene may lead to disordered fat metabolism. Furthermore, defects in this gene are linked to congenital diseases such as left-right axis malformations [5].
The huACVR2B mouse is a humanized model constructed using gene-editing technology. The sequence from exon 2 to 3'UTR of the mouse Acvr2b gene is in situ replaced with the sequence from exon 2 to 3'UTR of the human ACVR2B gene. This model can be used for research related to muscle atrophy and growth regulation, cancer cachexia intervention, and reproductive and gonadal functions, as well as the development of ACVR2B-targeted drugs.
Reference
Lee SJ, Reed LA, Davies MV, Girgenrath S, Goad ME, Tomkinson KN, Wright JF, Barker C, Ehrmantraut G, Holmstrom J, Trowell B, Gertz B, Jiang MS, Sebald SM, Matzuk M, Li E, Liang LF, Quattlebaum E, Stotish RL, Wolfman NM. Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18117-22.
Pyun JA, Kim S, Kwack K. Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure. Menopause. 2015 Feb;22(2):212-6.
Xu Z, Lv C, Gao J, Cui Y, Liu W, He Z, He L. LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity. Cell Mol Life Sci. 2024 Sep 10;81(1):391.
Huot JR, Pin F, Narasimhan A, Novinger LJ, Keith AS, Zimmers TA, Willis MS, Bonetto A. ACVR2B antagonism as a countermeasure to multi-organ perturbations in metastatic colorectal cancer cachexia. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1779-1798.
Kosaki R, Gebbia M, Kosaki K, Lewin M, Bowers P, Towbin JA, Casey B. Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 1999 Jan 1;82(1):70-6.
Strain Strategy
The sequences from exon 2 to 3'UTR of mouse Acvr2b gene were replaced with the sequences from exon 2 to 3'UTR of human ACVR2B gene.
Figure 1. Gene editing strategy of huACVR2B mice.
Application Area
Screening, development, and safety evaluation of ACVR2B-targeted drugs;
Research on cancer cachexia intervention;
Research on muscle atrophy and growth regulation;
Research on reproductive and gonadal functions.
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