hCldn18.2
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
hCldn18.2
Product ID
I001020
Gene Name
Background
C57BL/6NCya
Gene Alias
SFTA5; SFTPJ
Classification
Tumor Target Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
3
Document
Note: When using this mouse strain in a publication, please cite “hCldn18.2 mice (Catalog I001020) were purchased from Cyagen.”
Strain Description
This strain is a humanized mouse model of the Cldn18 gene. Through gene editing technology, the mouse Cldn18 gene is replaced with the human CLDN18.2 gene CDS sequence, while retaining the 3’UTR region of the mouse Cldn18 gene. Homozygous hCLDN18.2 mice are viable and fertile and can be used for the development and validation of CLDN18.2 targeted drugs and the study of the mechanism of gastrointestinal tumors.
Application Area
Development and screening of CLDN18.2 targeted drugs
Evaluation of the efficacy and safety of CLDN18.2 targeted drugs
Research on malignant tumors of the digestive tract
Validation Data