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hCldn18.2
Product ID:
I001020
Background:
C57BL/6NCya
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Strain Description
This strain is a humanized mouse model of the Cldn18 gene. Through gene editing technology, the mouse Cldn18 gene is replaced with the human CLDN18.2 gene CDS sequence, while retaining the 3’UTR region of the mouse Cldn18 gene. Homozygous hCLDN18.2 mice are viable and fertile and can be used for the development and validation of CLDN18.2 targeted drugs and the study of the mechanism of gastrointestinal tumors.
Application Area
Area
Development and screening of CLDN18.2 targeted drugs
Area
Evaluation of the efficacy and safety of CLDN18.2 targeted drugs
Area
Research on malignant tumors of the digestive tract
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