B6-hPD-1/hPD-L1
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hPD-1/hPD-L1
Product ID
I001202
Background
C57BL/6Cya
Gene Alias
PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1
Classification
Tumor Target Humanized Models,Immune Target Humanized Models
Phenotype
Chromosome
2
Document
Note: When using this mouse strain in a publication, please cite “B6-hPD-1/hPD-L1 mice (Catalog I001202) were purchased from Cyagen.”
Strain Description
B6-hPD-1/hPDL1 mice are PD-1 and CD274 double humanized mouse models obtained by mating PD-1 humanized mouse models with CD274 humanized mouse models. They express human PD-1 and CD274 genomic sequences under the control of mouse promoters. This model is a valuable tool for studying cancer immunotherapy. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting PD-1 and PD-L1.
Application Area
PD-1/PD-L1-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of cancer immunotherapy
Validation Data