B6-F8 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-F8 KO
Product ID
I001219
Gene Name
Background
C57BL/6JCya
Gene Alias
AHF; F8B; F8C; HEMA; FVIII; THPH13; DXS1253E
Classification
Rare Disease Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “B6-F8 KO mice (Catalog I001219) were purchased from Cyagen.”
Strain Description
The B6-F8 KO mouse is a hemophilia A (HA) research model developed through gene-editing techniques, where the murine F8 gene, homologous to the human F8 gene, is knocked out. Studies have shown that homozygous F8 knockout mice are viable and develop normally. Since the murine F8 gene is located on the X chromosome, hemizygous male and homozygous female B6-F8 KO mice exhibit a consistent phenotype with significantly lower FVIII activity compared to wild-type mice, prolonged clotting time, and a classic hemophilia A phenotype.
Application Area
Investigation of hemophilia A (HA) pathogenesis and the development and evaluation of therapeutic agents
Studies on the coagulation cascade process
Validation Data