Ccl6, a C-C motif chemokine ligand, plays crucial roles in various biological processes. It is involved in immune-related pathways, interacting with its receptor CCR1. Ccl6 has significance in inflammation, wound healing, and tumor-related processes [1-3, 7-10]. Genetic models, like gene knockout mouse models, are valuable for studying its functions.

In eosinophil-related studies, eosinophils promote tumor cell migration and metastasis by secreting Ccl6. Genetic knockout of Ccl6 in Il-5 Tg mice remarkably attenuates bone metastasis, indicating Ccl6's role in tumor metastasis [1]. In skin wound healing, Ccl6 promotes M2 polarization of macrophages, inhibits macrophage autophagy, and accelerates wound healing through the PI3-kinase/Akt signalling pathway [2]. In allergic airway inflammation, Ccl6-CCR1 axis is involved in the crosstalk between eosinophils and hematopoietic stem cells, as Ccl6 knockout mice show decreased eosinophil differentiation and airway inflammation [3].

In conclusion, Ccl6 is essential in multiple biological processes. Gene knockout mouse models have revealed its significant roles in tumor metastasis, skin wound healing, and allergic airway inflammation, providing insights into potential therapeutic strategies for related diseases.