C57BL/6JCya-Gga3em1flox/Cya
Common Name
Gga3-flox
Product ID
S-CKO-09520
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-260302-Gga3-B6J-VA
Status
When using this mouse strain in a publication, please cite “Gga3-flox Mouse (Catalog S-CKO-09520) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Gga3-flox
Strain ID
CKOCMP-260302-Gga3-B6J-VA
Gene Name
Product ID
S-CKO-09520
Gene Alias
mKIAA0154, C230037M19Rik
Background
C57BL/6JCya
Gene Full Name
golgi associated, gamma adaptin ear containing, ARF binding protein 3
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 11 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000019135
NCBI Transcript ID
NM_173048
Target Region
Exon 2~3
Size of Effective Region
~1.6 kb
Overview of Gene Research
Gga3, also known as Golgi-associated, γ adaptin ear containing, ADP-ribosylation factor-binding protein 3, is involved in multiple cellular processes. It plays a role in the recycling and signaling of G protein-coupled receptors (GPCRs), such as regulating the recycling and signaling of the PGD2 receptor DP1 through a Rab4-dependent mechanism [2]. It also participates in the anterograde trafficking of nascent GPCRs, like modulating the cell surface export of α2-adrenergic receptors [3]. Additionally, it is involved in the endocytic recycling of receptor tyrosine kinases, for example, mediating the endocytic recycling of TrkA to promote sustained Akt phosphorylation and cell survival [5].
In Gga3 gene-deleted C57BL/6J mice, fasting blood glucose levels are elevated, indicating its potential role in glucose metabolism [1]. Gga3 deletion and a GGA3 rare variant associated with late-onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings, suggesting its significance in Alzheimer's disease pathogenesis [4].
In conclusion, Gga3 is a multifunctional protein involved in receptor trafficking, cell survival, and glucose metabolism. Studies using Gga3-deleted mouse models have revealed its importance in glucose-related physiological processes and Alzheimer's disease, providing valuable insights into the underlying biological mechanisms and potential disease-related pathways.
References：
1. Zhang, Xiaohong, Yue, Song, Jiang, Dongjun, Liu, Jianli, Li, Xuezhi. 2023. Gga3 gene-deleted C57BL/6J mice have elevated fasting blood glucose levels. In Genes & diseases, 10, 2206-2209. doi:10.1016/j.gendis.2023.02.031. https://pubmed.ncbi.nlm.nih.gov/37554210/
2. Fréchette, Louis, Binda, Chantal, Génier, Samuel, Boisvert, Marilou, Parent, Jean-Luc. 2020. GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D2 in a Rab4-dependent mechanism. In Cellular signalling, 72, 109641. doi:10.1016/j.cellsig.2020.109641. https://pubmed.ncbi.nlm.nih.gov/32334026/
3. Zhang, Maoxiang, Davis, Jason E, Li, Chunman, Terry, Alvin V, Wu, Guangyu. 2016. GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export. In Molecular and cellular biology, 36, 1152-63. doi:10.1128/MCB.00009-16. https://pubmed.ncbi.nlm.nih.gov/26811329/
4. Lomoio, Selene, Willen, Rachel, Kim, WonHee, Tanzi, Rudolph E, Tesco, Giuseppina. . Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings. In Science translational medicine, 12, . doi:10.1126/scitranslmed.aba1871. https://pubmed.ncbi.nlm.nih.gov/33208500/
5. Li, Xuezhi, Lavigne, Pierre, Lavoie, Christine. 2015. GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. In Molecular biology of the cell, 26, 4412-26. doi:10.1091/mbc.E15-02-0087. https://pubmed.ncbi.nlm.nih.gov/26446845/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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