C57BL/6JCya-Trank1em1flox/Cya
Common Name
Trank1-flox
Product ID
S-CKO-10438
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-320429-Trank1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Trank1-flox Mouse (Catalog S-CKO-10438) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Trank1-flox
Strain ID
CKOCMP-320429-Trank1-B6J-VA
Gene Name
Product ID
S-CKO-10438
Gene Alias
Lba1, Gm187, A230061D21Rik, C030048J01Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000078626
NCBI RefSeq
NM_001164659
Target Region
Exon 5~6
Size of Effective Region
~1.0 kb
Overview of Gene Research
TRANK1, also known as Tetratricopeptide repeat and ankyrin repeat containing 1, is significantly associated with bipolar disorder (BD). Genes highly correlated with TRANK1 are enriched in biological processes related to dendritic spine, synaptic plasticity, axon guidance, and circadian entrainment [2].
In BD, the administration of type 1 interferon can induce the expression of TRANK1, which is associated with elevated circulating biomarkers of the impaired blood-brain barrier. Intestine microbiota-dependent type 1 interferon signalling may induce the over-expression of TRANK1, compromising the integrity of the blood-brain barrier (BBB) and contributing to BD [1].
In a mice model, fecal microbiota transplantation (FMT) with 'BD microbiota' led to a depression-like phenotype, elevated mRNA levels of inflammatory cytokines and TRANK1 in the hippocampus and prefrontal cortex. In vitro, LPS treatment activated pro-inflammatory factor secretion in BV-2 cells, upregulating neuronal TRANK1 mRNA expression [3].
In conclusion, TRANK1 is strongly linked to bipolar disorder and may be involved in the disruption of the blood-brain barrier and neuroinflammation, potentially through microbiota-gut-brain axis modulation. Understanding TRANK1's role could provide new insights into the pathophysiology of BD and other related psychiatric disorders.
References：
1. Lai, Jianbo, Jiang, Jiajun, Zhang, Peifen, Zhu, Yiyi, Hu, Shaohua. 2021. Impaired blood-brain barrier in the microbiota-gut-brain axis: Potential role of bipolar susceptibility gene TRANK1. In Journal of cellular and molecular medicine, 25, 6463-6469. doi:10.1111/jcmm.16611. https://pubmed.ncbi.nlm.nih.gov/34014031/
2. Li, Wenqiang, Cai, Xin, Li, Hui-Juan, Lv, Luxian, Chang, Hong. 2020. Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder. In Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 46, 1103-1112. doi:10.1038/s41386-020-00788-4. https://pubmed.ncbi.nlm.nih.gov/32791513/
3. Lai, Jianbo, Zhang, Peifen, Jiang, Jiajun, Zheng, Peng, Hu, Shaohua. 2021. New Evidence of Gut Microbiota Involvement in the Neuropathogenesis of Bipolar Depression by TRANK1 Modulation: Joint Clinical and Animal Data. In Frontiers in immunology, 12, 789647. doi:10.3389/fimmu.2021.789647. https://pubmed.ncbi.nlm.nih.gov/34992606/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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