Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Trank1em1flox/Cya
Common Name:
Trank1-flox
Product ID:
S-CKO-10438
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Trank1-flox
Strain ID
CKOCMP-320429-Trank1-B6J-VA
Gene Name
Trank1
Product ID
S-CKO-10438
Gene Alias
A230061D21Rik; C030048J01Rik; Gm187; Lba1
Background
C57BL/6JCya
NCBI ID
320429
Modification
Conditional knockout
Chromosome
9
Phenotype
MGI:1341834
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Trank1em1flox/Cya mice (Catalog S-CKO-10438) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000078626
NCBI RefSeq
NM_001164659
Target Region
Exon 5~6
Size of Effective Region
~1.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
TRANK1, also known as Tetratricopeptide repeat and ankyrin repeat containing 1, is significantly associated with bipolar disorder (BD). Genes highly correlated with TRANK1 are enriched in biological processes related to dendritic spine, synaptic plasticity, axon guidance, and circadian entrainment [2].

In BD, the administration of type 1 interferon can induce the expression of TRANK1, which is associated with elevated circulating biomarkers of the impaired blood-brain barrier. Intestine microbiota-dependent type 1 interferon signalling may induce the over-expression of TRANK1, compromising the integrity of the blood-brain barrier (BBB) and contributing to BD [1].

In a mice model, fecal microbiota transplantation (FMT) with 'BD microbiota' led to a depression-like phenotype, elevated mRNA levels of inflammatory cytokines and TRANK1 in the hippocampus and prefrontal cortex. In vitro, LPS treatment activated pro-inflammatory factor secretion in BV-2 cells, upregulating neuronal TRANK1 mRNA expression [3].

In conclusion, TRANK1 is strongly linked to bipolar disorder and may be involved in the disruption of the blood-brain barrier and neuroinflammation, potentially through microbiota-gut-brain axis modulation. Understanding TRANK1's role could provide new insights into the pathophysiology of BD and other related psychiatric disorders.

References:
1. Lai, Jianbo, Jiang, Jiajun, Zhang, Peifen, Zhu, Yiyi, Hu, Shaohua. 2021. Impaired blood-brain barrier in the microbiota-gut-brain axis: Potential role of bipolar susceptibility gene TRANK1. In Journal of cellular and molecular medicine, 25, 6463-6469. doi:10.1111/jcmm.16611. https://pubmed.ncbi.nlm.nih.gov/34014031/
2. Li, Wenqiang, Cai, Xin, Li, Hui-Juan, Lv, Luxian, Chang, Hong. 2020. Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder. In Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 46, 1103-1112. doi:10.1038/s41386-020-00788-4. https://pubmed.ncbi.nlm.nih.gov/32791513/
3. Lai, Jianbo, Zhang, Peifen, Jiang, Jiajun, Zheng, Peng, Hu, Shaohua. 2021. New Evidence of Gut Microbiota Involvement in the Neuropathogenesis of Bipolar Depression by TRANK1 Modulation: Joint Clinical and Animal Data. In Frontiers in immunology, 12, 789647. doi:10.3389/fimmu.2021.789647. https://pubmed.ncbi.nlm.nih.gov/34992606/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest