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C57BL/6JCya-Pdp1em1flox/Cya
Common Name:
Pdp1-flox
Product ID:
S-CKO-10950
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Pdp1-flox
Strain ID
CKOCMP-381511-Pdp1-B6J-VA
Gene Name
Pdp1
Product ID
S-CKO-10950
Gene Alias
Gm1024; Ppm2c
Background
C57BL/6JCya
NCBI ID
381511
Modification
Conditional knockout
Chromosome
4
Phenotype
MGI:2685870
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Pdp1em1flox/Cya mice (Catalog S-CKO-10950) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000108297
NCBI RefSeq
NM_001033453
Target Region
Exon 2
Size of Effective Region
~5.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Pdp1, short for pyruvate dehydrogenase phosphatase catalytic subunit 1, is a key enzyme in the metal-dependent Ser/Thr protein phosphatase PPM family [6]. It dephosphorylates and activates pyruvate dehydrogenase (PDH), stimulating the conversion of pyruvate into acetyl-CoA, thus playing a vital role in cellular energy metabolism [3]. It is also involved in multiple signaling pathways, such as the RAS signaling axis, MAPK signaling, and JAK/STAT3 signaling pathway, and is of great biological importance in various physiological and pathological processes [1,2,4].

In FLT3-ITD-positive acute myeloid leukemia (AML), Pdp1 knockdown reduces cellular respiration and impairs the proliferation of FLT3-ITD cells, and Pdp1 modifies the response to FLT3 inhibition, enhancing or diminishing drug resistance [1]. In KRAS mutant colorectal cancer, Pdp1 acts as a scaffold to enhance BRAF and MEK1 interaction, accelerating cancer progression, and targeting Pdp1 combined with MAPK inhibitors can inhibit the cancer [2]. In breast cancer, Pdp1 knockdown suppresses cell amplification, migration, and triggers apoptosis through the STAT3 pathway [4]. In ovarian cancer, Pdp1 promotes cell proliferation, invasion, and migration, and is associated with patient prognosis and chemosensitivity [5]. In Drosophila, Pdp1 is part of a secondary feedback loop in the circadian clock, and its interaction with TARANIS and VRILLE modulates the circadian transcriptional feedback mechanism [7,8]. In crickets, Pdp1 plays important roles in the circadian clock [9].

In conclusion, Pdp1 is a crucial regulator in multiple biological processes. Its functions in energy metabolism and various signaling pathways contribute to the development and progression of many diseases, including AML, colorectal cancer, breast cancer, and ovarian cancer. The study of Pdp1 using gene-knockout or other loss-of-function models has provided valuable insights into its role in these disease conditions, facilitating a better understanding of the underlying mechanisms and potentially leading to new therapeutic strategies.

References:
1. Alshamleh, Islam, Kurrle, Nina, Makowka, Philipp, Schwalbe, Harald, Serve, Hubert. 2023. PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia. In Leukemia, 37, 2367-2382. doi:10.1038/s41375-023-02041-5. https://pubmed.ncbi.nlm.nih.gov/37935978/
2. Yuan, Ming, Zhang, Chi, Chen, Shaopeng, Wu, Xianrui, Lan, Ping. 2024. PDP1 promotes KRAS mutant colorectal cancer progression by serving as a scaffold for BRAF and MEK1. In Cancer letters, 597, 217007. doi:10.1016/j.canlet.2024.217007. https://pubmed.ncbi.nlm.nih.gov/38849010/
3. Karagiota, Angeliki, Kanoura, Amalia, Paraskeva, Efrosyni, Simos, George, Chachami, Georgia. 2022. Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia. In The FEBS journal, 290, 2165-2179. doi:10.1111/febs.16694. https://pubmed.ncbi.nlm.nih.gov/36453802/
4. Wang, Yufeng, Dang, Huifen, Qiao, Hui, Tian, Yinxia, Guan, Quanlin. . PDP1 promotes the progression of breast cancer through STAT3 pathway. In Cell biochemistry and function, 42, e3994. doi:10.1002/cbf.3994. https://pubmed.ncbi.nlm.nih.gov/38566355/
5. Song, Yan, Zhang, Juan, Zhang, Lei, Zhang, Suxia, Shen, Chengcheng. 2022. PDP1 Promotes Cell Malignant Behavior and Is Associated with Worse Clinical Features in Ovarian Cancer Patients: Evidence from Bioinformatics and In Vitro Level. In Computational and mathematical methods in medicine, 2022, 7397250. doi:10.1155/2022/7397250. https://pubmed.ncbi.nlm.nih.gov/36276992/
6. Kamada, Rui, Kudoh, Fuki, Ito, Shogo, Omichinski, James G, Sakaguchi, Kazuyasu. 2020. Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors. In Pharmacology & therapeutics, 215, 107622. doi:10.1016/j.pharmthera.2020.107622. https://pubmed.ncbi.nlm.nih.gov/32650009/
7. Akpoghiran, Oghenerukevwe, Afonso, Dinis J S, Zhang, Yanan, Koh, Kyunghee. 2023. TARANIS interacts with VRILLE and PDP1 to modulate the circadian transcriptional feedback mechanism in Drosophila. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.05.19.541420. https://pubmed.ncbi.nlm.nih.gov/38076905/
8. Cyran, Shawn A, Buchsbaum, Anna M, Reddy, Karen L, Storti, Robert V, Blau, Justin. . vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. In Cell, 112, 329-41. doi:. https://pubmed.ncbi.nlm.nih.gov/12581523/
9. Narasaki-Funo, Yumina, Tomiyama, Yasuaki, Nose, Motoki, Bando, Tetsuya, Tomioka, Kenji. 2020. Functional analysis of Pdp1 and vrille in the circadian system of a cricket. In Journal of insect physiology, 127, 104156. doi:10.1016/j.jinsphys.2020.104156. https://pubmed.ncbi.nlm.nih.gov/33058831/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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