C57BL/6JCya-Ccdc27em1flox/Cya
Common Name
Ccdc27-flox
Product ID
S-CKO-10960
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-381580-Ccdc27-B6J-VA
Status
When using this mouse strain in a publication, please cite “Ccdc27-flox Mouse (Catalog S-CKO-10960) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ccdc27-flox
Strain ID
CKOCMP-381580-Ccdc27-B6J-VA
Gene Name
Product ID
S-CKO-10960
Gene Alias
Gm1035
Background
C57BL/6JCya
Gene Full Name
coiled-coil domain containing 27
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 4 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000047207
NCBI Transcript ID
NM_001033455
Target Region
Exon 2
Size of Effective Region
~0.7 kb
Overview of Gene Research
Ccdc27, with currently no well-known common aliases, is potentially involved in genetic regulation related to bone mineral density (BMD). However, its exact essential function, associated pathways at a molecular level remain to be fully elucidated. Understanding its function could be facilitated through genetic models such as gene knockout (KO) or conditional knockout (CKO) mouse models for in-vivo functional studies.
A study analyzing a high-density SNP panel on chromosome 1p36 in 39 osteoporosis pedigrees found that Ccdc27 is among the candidate genes potentially associated with BMD. Linkage and linkage disequilibrium analyses were performed, and Ccdc27 was identified as having at least one SNP with p < 0.001 for at least one BMD trait, suggesting its possible role in controlling BMD [1].
In conclusion, Ccdc27 appears to be a candidate gene related to BMD, potentially playing a role in the genetic regulation of bone health. Although no KO/CKO mouse model findings were presented in the given reference, the identification in the human pedigree study indicates its importance in understanding the genetic basis of low BMD, which could potentially lead to new insights in osteoporosis research.
References：
1. Zhang, H, Sol-Church, K, Rydbeck, H, Spotila, L D, Devoto, M. 2008. High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density. In Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 20, 341-6. doi:10.1007/s00198-008-0668-1. https://pubmed.ncbi.nlm.nih.gov/18597038/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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