C57BL/6JCya-Angptl7em1flox/Cya
Common Name
Angptl7-flox
Product ID
S-CKO-12827
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-654812-Angptl7-B6J-VA
Status
When using this mouse strain in a publication, please cite “Angptl7-flox Mouse (Catalog S-CKO-12827) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Angptl7-flox
Strain ID
CKOCMP-654812-Angptl7-B6J-VA
Gene Name
Product ID
S-CKO-12827
Gene Alias
--
Background
C57BL/6JCya
Gene Full Name
angiopoietin-like 7
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 4 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000030840
NCBI Transcript ID
NM_001039554
Target Region
Exon 2~3
Size of Effective Region
~1.6 kb
Overview of Gene Research
Angptl7, a member of the angiopoietin-like protein family, is involved in multiple biological processes. It has been associated with angiogenesis, inflammation, and is known to play a role in the regulation of insulin resistance, with potential implications in type 2 diabetes mellitus [4]. Additionally, it participates in the regulation of intra-ocular pressure (IOP), making it relevant in glaucoma research [1,3,5].
In mouse models, Angptl7 knockout (KO) mice have lower basal IOP compared to wild-type mice, with heterozygotes also showing a trend towards lower IOP [1]. Increasing murine Angptl7 levels via injection into mouse eyes increases IOP, and acute Angptl7 silencing in adult mice lowers the IOP, similar to the observations in KO mice [1]. In the context of acute myeloid leukemia (AML), knocking out Id1 in mesenchymal cells, which reduces Angptl7 levels, significantly suppresses the proliferation of cocultured AML cells and impairs AML progression in mouse models [2].
In conclusion, Angptl7 is crucial for IOP homeostasis and may be a therapeutic target for glaucoma. Its role in promoting insulin resistance suggests it could be relevant in diabetes-related research. The use of Angptl7 KO mouse models has provided key insights into its functions in IOP regulation and AML progression, highlighting its importance in these disease areas.
References：
1. Praveen, Kavita, Patel, Gaurang C, Gurski, Lauren, Romano, Carmelo, Coppola, Giovanni. 2022. ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma. In Communications biology, 5, 1051. doi:10.1038/s42003-022-03932-6. https://pubmed.ncbi.nlm.nih.gov/36192519/
2. Fei, Ming-Yue, Wang, Yong, Chang, Bin-He, Sun, Xiao-Jian, Wang, Lan. . The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment. In Blood, 142, 903-917. doi:10.1182/blood.2022019537. https://pubmed.ncbi.nlm.nih.gov/37319434/
3. Brown, Suzette Farber-Katz, Nguyen, Hien, Mzyk, Philip, Peterson, Andrew, Stamer, W Daniel. . ANGPTL7 and Its Role in IOP and Glaucoma. In Investigative ophthalmology & visual science, 65, 22. doi:10.1167/iovs.65.3.22. https://pubmed.ncbi.nlm.nih.gov/38497513/
4. Xu, Tong, Xu, Lilei, Meng, Panpan, Zhou, Yaru, Feng, Mingqian. 2020. Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34, 13548-13560. doi:10.1096/fj.202000246RR. https://pubmed.ncbi.nlm.nih.gov/32786125/
5. Sun, Mengsha, Liu, Wenjia, Zhou, Minwen. 2022. ANGPTL7 is transcriptionally regulated by SP1 and modulates glucocorticoid-induced cross-linked actin networks in trabecular meshwork cells via the RhoA/ROCK pathway. In Cell death discovery, 8, 50. doi:10.1038/s41420-022-00847-3. https://pubmed.ncbi.nlm.nih.gov/35136015/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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