C57BL/6JCya-Gipc1em1flox/Cya
Common Name:
Gipc1-flox
Product ID:
S-CKO-13955
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Gipc1-flox
Strain ID
CKOCMP-67903-Gipc1-B6J-VA
Gene Name
Product ID
S-CKO-13955
Gene Alias
GIPC; Glut1CIP; Rgs19ip1; Semcap1; TIP-2; TaxIP2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
8
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gipc1em1flox/Cya mice (Catalog S-CKO-13955) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000019577
NCBI RefSeq
NM_018771
Target Region
Exon 2~4
Size of Effective Region
~2.1 kb
Detailed Document
Overview of Gene Research
GIPC1, also known as GAIP interacting protein, C terminus 1, is a multifunctional scaffold protein. It plays diverse roles in multiple biological processes. It binds to various proteins and is involved in signaling pathways such as PDGFR/PI3K/AKT, and is associated with the regulation of cell proliferation, migration, and metastasis. It also interacts with β1 -adrenergic receptor, influencing cardiac function, and is related to lipid and cholesterol metabolism through its interaction with SR-B1 [2,3,4].
In mouse models, GIPC1 knockdown reduced MACC1-induced cell migration and invasion, and suppressed tumor growth and metastasis in mice transplanted with MACC1-overexpressing CRC cells, indicating its role in cancer metastasis [1]. In gastric cancer, GIPC1 knockdown blocked the PDGFR/PI3K/AKT signaling pathway, inhibiting cell proliferation and migration, while overexpression had the opposite effects [2]. GIPC1 cKO mice showed spontaneous cardiac hypertrophy, fibrosis, and systolic dysfunction, while AAV9-mediated GIPC1 overexpression attenuated isoproterenol-induced pathological cardiac remodelling in mice [3].
In conclusion, GIPC1 is crucial in processes like cancer metastasis, cell proliferation, migration, and cardiac function. Studies using gene knockout and overexpression models in mice have revealed its role in cancer and cardiac diseases, providing insights into potential therapeutic targets for these conditions.
References:
1. Siegel, Franziska, Schmidt, Hannes, Juneja, Manisha, Schlag, Peter M, Stein, Ulrike. 2023. GIPC1 regulates MACC1-driven metastasis. In Frontiers in oncology, 13, 1280977. doi:10.3389/fonc.2023.1280977. https://pubmed.ncbi.nlm.nih.gov/38144523/
2. Li, Tingting, Zhong, Wei, Yang, Liu, Song, Gang, Luo, Fanghong. 2023. GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling. In Oncology research, 32, 361-371. doi:10.32604/or.2023.043807. https://pubmed.ncbi.nlm.nih.gov/38186571/
3. Sun, Xi, Han, Yanna, Yu, Yahan, Zhao, Dan, Bai, Yunlong. 2024. Overexpressing of the GIPC1 protects against pathological cardiac remodelling. In European journal of pharmacology, 971, 176488. doi:10.1016/j.ejphar.2024.176488. https://pubmed.ncbi.nlm.nih.gov/38458410/
4. Zhang, Ziyu, Zhou, Qian, Liu, Rui, Guo, Zhigang, Hu, Zhigang. 2021. The adaptor protein GIPC1 stabilizes the scavenger receptor SR-B1 and increases its cholesterol uptake. In The Journal of biological chemistry, 296, 100616. doi:10.1016/j.jbc.2021.100616. https://pubmed.ncbi.nlm.nih.gov/33811857/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen