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C57BL/6JCya-Cenplem1flox/Cya
Common Name:
Cenpl-flox
Product ID:
S-CKO-14831
Background:
C57BL/6JCya
Product Type
Age
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Sex
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Basic Information
Strain Name
Cenpl-flox
Strain ID
CKOCMP-70454-Cenpl-B6J-VA
Gene Name
Cenpl
Product ID
S-CKO-14831
Gene Alias
2610300B10Rik; CENP-L
Background
C57BL/6JCya
NCBI ID
70454
Modification
Conditional knockout
Chromosome
1
Phenotype
MGI:1917704
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cenplem1flox/Cya mice (Catalog S-CKO-14831) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000111620
NCBI RefSeq
NM_001159930
Target Region
Exon 4
Size of Effective Region
~1.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cenpl, or Centromere protein L, is an important member of the centromere protein (CENP) family. It is involved in the mitotic process of eukaryotic cells, playing a crucial role in cell division. The gene is associated with multiple biological pathways, and its abnormal expression can have significant impacts on cell function and organism health [1,4].

Cenpl has been extensively studied in the context of cancer. In most cancers, Cenpl is up-regulated, and its overexpression and mutation are linked to a poorer prognosis [1]. For example, in lung adenocarcinoma (LUAD), Cenpl regulates cell proliferation and the cell cycle, and is negatively correlated with the inflammation level. Knockdown of Cenpl significantly suppresses the expression of CDK2 and CCNE2, and induces G0/G1 arrest and apoptosis of LUAD cells [1]. In breast cancer, high Cenpl expression is related to the cell cycle, nuclear division, organelle fission, and chromosome segregation. Knockdown of Cenpl decreases breast cancer cells' ability to proliferate and migrate [3]. In hepatocellular carcinoma (HCC), Cenpl is significantly up-regulated, and it accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway [4]. In pancreatic adenocarcinoma, overexpression of Cenpl mRNA is significantly correlated with the poor prognosis of patients [2].

In conclusion, Cenpl is essential for the normal mitotic process in eukaryotic cells. Research using gene-knockdown models in cancer cells has revealed its significant role in cancer development, including promoting cell proliferation, influencing the cell cycle, and being associated with poor prognosis in multiple cancer types. These findings suggest that Cenpl could potentially serve as a biomarker and therapeutic target in cancer treatment.

References:
1. Feng, Ziyang, Chen, Yu, Cai, Changjing, Zeng, Shan, Han, Ying. 2022. Pan-Cancer and Single-Cell Analysis Reveals CENPL as a Cancer Prognosis and Immune Infiltration-Related Biomarker. In Frontiers in immunology, 13, 916594. doi:10.3389/fimmu.2022.916594. https://pubmed.ncbi.nlm.nih.gov/35844598/
2. Cui, Zhongyuan, Du, Ling, Wang, Jielong, Chen, Gang, Wu, Zhixian. 2022. Overexpression of CENPL mRNA potentially regulated by miR-340-3p predicts the prognosis of pancreatic cancer patients. In BMC cancer, 22, 1354. doi:10.1186/s12885-022-10450-5. https://pubmed.ncbi.nlm.nih.gov/36572856/
3. Gui, Zhengwei, Tian, Yao, Liu, Shiyang, Liu, Chenguang, Zhang, Lin. 2023. Highly expressed CENPL is correlated with breast cancer cell proliferation and immune infiltration. In Frontiers in oncology, 13, 1046774. doi:10.3389/fonc.2023.1046774. https://pubmed.ncbi.nlm.nih.gov/36816951/
4. He, Kun, Xie, Mengyi, Hong, Weifeng, You, Chuan, Li, Jingdong. 2023. CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma. In The international journal of biochemistry & cell biology, 166, 106481. doi:10.1016/j.biocel.2023.106481. https://pubmed.ncbi.nlm.nih.gov/37914022/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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