C57BL/6JCya-Tex22em1flox/Cya
Common Name:
Tex22-flox
Product ID:
S-CKO-16298
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tex22-flox
Strain ID
CKOCMP-75671-Tex22-B6J-VA
Gene Name
Product ID
S-CKO-16298
Gene Alias
1700028O09Rik; Tep22
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
12
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tex22em1flox/Cya mice (Catalog S-CKO-16298) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000012355
NCBI RefSeq
NM_029381
Target Region
Exon 3
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Tex22 is one of the genes located within a 0.305 Mb region on chromosome 14q32.33 [1]. While its exact function, associated pathways, and overall biological importance are not elaborated in the provided references, studies on genes in this region can potentially shed light on its role.
In a case report, a child with a microdeletion of chromosome 14q32.33, which includes Tex22 along with five other genes, presented with mild facial dysmorphisms and intellectual disability similar to patients with larger deletions of the long arm of chromosome 14. This suggests that the genes in this deletion, including Tex22, may contribute to the 14q32 deletion syndrome [1]. Additionally, Tex22 was identified as one of the protein-coding genes in a CRC-related competing endogenous RNA (ceRNA) network, with significantly high expression in colorectal cancer (CRC) according to validations in independent datasets [2].
In conclusion, Tex22 may play a role in the 14q32 deletion syndrome as indicated by the chromosomal deletion case, and its high expression in CRC implies a possible involvement in colorectal cancer development. Further functional studies, potentially using gene knockout or conditional knockout mouse models, could help elucidate its precise biological functions and its significance in these disease conditions.
References:
1. Holder, J Lloyd, Lotze, Timothy E, Bacino, Carlos, Cheung, Sau-Wai. 2012. A child with an inherited 0.31 Mb microdeletion of chromosome 14q32.33: further delineation of a critical region for the 14q32 deletion syndrome. In American journal of medical genetics. Part A, 158A, 1962-6. doi:10.1002/ajmg.a.35289. https://pubmed.ncbi.nlm.nih.gov/22488736/
2. Li, Lifang, Ruan, Jingxiong, Ma, Yanfen, Tian, Xudong, Hu, Jian. 2023. Identification of key modules and micro RNAs associated with colorectal cancer via a weighted gene co-expression network analysis and competing endogenous RNA network analysis. In Journal of gastrointestinal oncology, 14, 1320-1330. doi:10.21037/jgo-23-244. https://pubmed.ncbi.nlm.nih.gov/37435199/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen