C57BL/6JCya-Slco2a1em1flox/Cya
Common Name:
Slco2a1-flox
Product ID:
S-CKO-17504
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slco2a1-flox
Strain ID
CKOCMP-24059-Slco2a1-B6J-VC
Gene Name
Product ID
S-CKO-17504
Gene Alias
2310021C19Rik; OATP2A1; PHOAR2; Pgt; Slc21a2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slco2a1em1flox/Cya mice (Catalog S-CKO-17504) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000035148
NCBI RefSeq
NM_033314
Target Region
Exon 4~6
Size of Effective Region
~3.3 kb
Detailed Document
Overview of Gene Research
Slco2a1, also known as PGT, OATP2A1, PHOAR2, or SLC21A2, is a plasma membrane transporter with 12 transmembrane domains. It ubiquitously expressed in tissues, mediates the membrane transport of prostaglandins (PGs, mainly PGE2, PGF2α, PGD2) and thromboxanes (e.g., TxB2), and is involved in the metabolic clearance of prostaglandins. PGs imported by it are oxidized by cytoplasmic 15-hydroxyprostaglandin dehydrogenase. SLCO2A1 is also part of the Maxi-Cl channel, regulating anion fluxes [1,5].
SLCO2A1-related knockout studies are not directly mentioned in the provided abstracts. However, whole-exome analyses suggest that recessive inheritance of its mutations is associated with primary hypertrophic osteoarthropathy (PHO) and chronic enteropathy associated with SLCO2A1 (CEAS). In PHO, mutations in SLCO2A1 disturb PGE2 catabolism, leading to increased circulating PGE2 levels. In CEAS, multiple ulcers in the small intestine with chronic bleeding and protein loss occur, likely due to elevated PGE2 levels [1,2,3,4].
In conclusion, Slco2a1 is crucial for the transport and metabolism of prostaglandins. Its mutations are associated with PHO and CEAS, highlighting its significance in these disease conditions. Understanding Slco2a1 can potentially provide new insights into the pathophysiology of these refractory diseases and guide the development of targeted therapies [1,2,3,4].
References:
1. Nakanishi, Takeo, Nakamura, Yoshinobu, Umeno, Junji. 2021. Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action. In Pharmacology & therapeutics, 223, 107803. doi:10.1016/j.pharmthera.2021.107803. https://pubmed.ncbi.nlm.nih.gov/33465398/
2. Xie, Zhi-Xin, Li, Yue, Yang, Ai-Ming, Wu, Dong, Wang, Qiang. . Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene: Hypotheses and conundrums. In World journal of gastroenterology, 30, 2505-2511. doi:10.3748/wjg.v30.i19.2505. https://pubmed.ncbi.nlm.nih.gov/38817656/
3. Xu, Yang, Zhang, Zeng, Yue, Hua, Li, Shanshan, Zhang, Zhenlin. 2021. Monoallelic mutations in SLCO2A1 cause autosomal dominant primary hypertrophic osteoarthropathy. In Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36, 1459-1468. doi:10.1002/jbmr.4310. https://pubmed.ncbi.nlm.nih.gov/33852188/
4. Kimball, Tamara N, Rivero-García, Pamela, Barrera-Godínez, Alejandro, Domínguez-Cherit, Judith. 2023. Genotype and phenotype characterization of primary hypertrophic osteoarthropathy type 2 and chronic enteropathy associated with SLCO2A1: Report of two cases and literature review. In American journal of medical genetics. Part A, 194, e63446. doi:10.1002/ajmg.a.63446. https://pubmed.ncbi.nlm.nih.gov/37915296/
5. Nakanishi, Takeo, Tamai, Ikumi. 2017. Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins. In The AAPS journal, 20, 13. doi:10.1208/s12248-017-0163-8. https://pubmed.ncbi.nlm.nih.gov/29204966/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen