Cpne7, also known as copine-7, is involved in multiple biological processes. It plays a crucial role in the maintenance and homeostasis of odontoblasts, promoting their differentiation from progenitor cells. It also impacts periodontal ligament regeneration. In addition, Cpne7 is associated with the regulation of amyloidogenesis in Alzheimer's disease and is implicated in colorectal tumorigenesis [1,2,4,3].

In the dental pulp, Cpne7 -null mice exhibit accelerated cellular senescence in odontoblasts due to oxidative stress and DNA damage accumulation, leading to impaired odontoblast survival and aberrant dentin formation [1]. In contrast, Cpne7 -overexpressing transgenic mice show a healthy dentin-pulp complex and physiologic dentin regeneration. In colorectal cancer, knockdown of Cpne7 inhibits cell proliferation, colony formation, and metastasis, while promoting apoptosis. Delivery of Cpne7 shRNA hinders tumor growth in vivo [3,5,6].

In conclusion, Cpne7 is essential for maintaining the proper function of odontoblasts and periodontal tissues. In disease areas, Cpne7 plays a significant role in colorectal tumorigenesis, and its knockdown can enhance the chemosensitivity of colorectal cancer cells. The study of Cpne7 using gene knockout models has provided valuable insights into its function in dental and cancer-related biological processes.