Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Mdh1em1/Cya
Common Name:
Mdh1-KO
Product ID:
S-KO-03234
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Mdh1-KO
Strain ID
KOCMP-17449-Mdh1-B6J-VA
Gene Name
Mdh1
Product ID
S-KO-03234
Gene Alias
B230377B03Rik; KAR; MDH-s; MDHA; Mor-2; Mor2
Background
C57BL/6JCya
NCBI ID
17449
Modification
Conventional knockout
Chromosome
11
Phenotype
MGI:97051
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mdh1em1/Cya mice (Catalog S-KO-03234) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000238916
NCBI RefSeq
NM_001316675.1
Target Region
Exon 2~3
Size of Effective Region
~1.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Mdh1, short for malate dehydrogenase 1, is a key enzyme involved in the citrate cycle pathway [2]. It catalyzes the interconversion between malate and oxaloacetate, playing a crucial role in energy metabolism processes. This function is vital for various biological processes such as cell viability maintenance and metabolite regulation. Genetic models, like KO or CKO mouse models, can be valuable in further exploring its functions.

In acute liver failure (ALF), deacetylation of MDH1 at K118 promotes NETosis, a novel mode of cell death, and aggravates PANoptosis through endoplasmic reticulum stress signaling, thus accelerating the progression of ALF [1,3]. In acute lung injury (ALI), inactivation of MDH1 in the citrate cycle pathway affects the glycolysis of primary alveolar epithelial type II (AT2) cells. Restoring MDH1 function promotes AT2 cell vitality by increasing glucose intake, suggesting its potential as a therapeutic target for ALI [2]. In pancreatic ductal adenocarcinoma (PDAC), MDH1 is required for maintaining the levels of the essential autophagy initiator serine-threonine kinase ULK1 during autophagosome formation, regulating autophagy in PDAC cells [4].

In conclusion, MDH1 is essential for energy metabolism-related biological processes. Studies using model-based research, especially in relation to diseases like ALF, ALI, and PDAC, have revealed its role in cell death regulation, cell viability, and autophagy. These findings contribute to understanding the pathogenesis of these diseases and potentially developing new treatment strategies.

References:

1. Wang, Yukun, Shi, Chunxia, Guo, Jin, Zhang, Long, Gong, Zuojiong. 2024. IDH1/MDH1 deacetylation promotes acute liver failure by regulating NETosis. In Cellular & molecular biology letters, 29, 8. doi:10.1186/s11658-023-00529-7. https://pubmed.ncbi.nlm.nih.gov/38172700/

2. Hu, Mu, Yang, JieLai, Xu, Yang, Liu, Jiao. 2022. MDH1 and MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake. In Computational and mathematical methods in medicine, 2022, 2023500. doi:10.1155/2022/2023500. https://pubmed.ncbi.nlm.nih.gov/36158123/

3. Shi, Chunxia, Wang, Yukun, Guo, Jin, Zhang, Yanqiong, Gong, Zuojiong. 2024. Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling. In Cell death discovery, 10, 275. doi:10.1038/s41420-024-02054-8. https://pubmed.ncbi.nlm.nih.gov/38851781/

4. New, Maria, Van Acker, Tim, Sakamaki, Jun-Ichi, Howell, Michael, Tooze, Sharon A. 2019. MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma. In Cancer research, 79, 1884-1898. doi:10.1158/0008-5472.CAN-18-2553. https://pubmed.ncbi.nlm.nih.gov/30765601/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest