C57BL/6JCya-Cfap90em1/Cya
Common Name
Cfap90-KO
Product ID
S-KO-13026
Backgroud
C57BL/6JCya
Strain ID
KOCMP-69315-Cfap90-B6J-VB
When using this mouse strain in a publication, please cite “Cfap90-KO Mouse (Catalog S-KO-13026) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cfap90-KO
Strain ID
KOCMP-69315-Cfap90-B6J-VB
Gene Name
Product ID
S-KO-13026
Gene Alias
1700001L19Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 13
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000022007
NCBI RefSeq
NM_027035
Target Region
Exon 2~3
Size of Effective Region
~3.1 kb
Overview of Gene Research
Cfap90, information about its key aliases, associated pathways, and core functions is currently scarce based on the provided reference. However, it is one of the genes predominantly expressed in the mouse testis [1].
In a study using the CRISPR/Cas9 system to generate knockout mice for 12 testis-enriched genes, including Cfap90, it was found that the individual disruption of these genes did not affect male fertility. Mating tests revealed that Cfap90 knockout mice did not show any impairment in male fertility, indicating that this gene is not individually essential for male fertilization [1].
In conclusion, while Cfap90 is expressed predominantly in the mouse testis, its individual knockout does not impact male fertility, suggesting that it may not be a sole determinant in male infertility or a potential contraceptive target. The use of Cfap90 knockout mouse models in this study provided insights into the non-essential role of this gene in male fertility [1].
References:
1. Suzuki, Akira, Yabuta, Norikazu, Shimada, Keisuke, Matzuk, Martin M, Ikawa, Masahito. 2024. Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice. In Journal of reproductive immunology, 163, 104252. doi:10.1016/j.jri.2024.104252. https://pubmed.ncbi.nlm.nih.gov/38697008/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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