Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Ccdc106em1/Cya
Common Name:
Ccdc106-KO
Product ID:
S-KO-17596
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Ccdc106-KO
Strain ID
KOCMP-232821-Ccdc106-B6J-VB
Gene Name
Ccdc106
Product ID
S-KO-17596
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
232821
Modification
Conventional knockout
Chromosome
7
Phenotype
MGI:2385900
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ccdc106em1/Cya mice (Catalog S-KO-17596) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000108571
NCBI RefSeq
NM_001290429
Target Region
Exon 5~6
Size of Effective Region
~1.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
CCDC106, or coiled-coil domain-containing protein 106, has emerged as a significant player in multiple biological processes. It is involved in regulating the p53-Mdm2/MdmX signaling axis, which is crucial for maintaining the basal level of the tumor suppressor p53 [1]. By directly interacting with the p53 transactivation domain, CCDC106 competes with Mdm2 and MdmX, influencing the cellular levels of p53 and Mdm2/MdmX.

In cancer-related studies, CCDC106 knockdown enhanced apoptosis by stabilizing p53 and suppressed cell viability, colony formation, migration and invasion in cervical cancer HeLa and breast cancer MCF7 cells with wild-type p53, while overexpression had opposite effects in normal breast epithelial HBL100 and cervical cancer SiHa cells with wild-type p53 [5]. In ovarian cancer, overexpression of CCDC106 promoted proliferation, invasion and epithelial-to-mesenchymal transition (EMT) of mutant p53 ovarian cancer cells via the ATF4-mediated inhibition of p21 [2]. In non-small cell lung cancer, CCDC106 expression correlated with advanced TNM stage, positive regional lymph node metastasis and poor overall survival, and it promoted cell proliferation depending on AKT signaling [3]. Also, HPV-CCDC106 integration in cervical cancer altered local chromosome architecture, hijacked an enhancer, and promoted cancer progression by facilitating high CCDC106 expression after HPV E6 splicing, which led to p53 degradation [4,6].

In conclusion, CCDC106 has a significant impact on cancer-related biological processes, mainly through its interaction with p53 and involvement in cell-cycle-regulating and cancer-promoting pathways. Functional studies using gene knockout or knockdown models in various cancer cell lines have revealed its role in promoting cancer cell proliferation, invasion, and in some cases, p53 degradation. These findings suggest CCDC106 could be a potential therapeutic target in cancer treatment.

References:
1. Zhou, Ting, Ke, Zhiqiang, Ma, Qianqian, Cheng, Xiyao, Su, Zhengding. 2023. Molecular mechanism of CCDC106 regulating the p53-Mdm2/MdmX signaling axis. In Scientific reports, 13, 21892. doi:10.1038/s41598-023-47808-z. https://pubmed.ncbi.nlm.nih.gov/38081879/
2. Zhao, Na, Wang, Chen, Guo, Peng, Bhawal, Ujjal K, Liu, Yang. . CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway. In Bioengineered, 13, 10956-10972. doi:10.1080/21655979.2022.2066759. https://pubmed.ncbi.nlm.nih.gov/35484984/
3. Zhang, Xiupeng, Zheng, Qin, Wang, Chen, Qiu, Xueshan, Wang, Enhua. . CCDC106 promotes non-small cell lung cancer cell proliferation. In Oncotarget, 8, 26662-26670. doi:10.18632/oncotarget.15792. https://pubmed.ncbi.nlm.nih.gov/28460455/
4. Cao, Canhui, Hong, Ping, Huang, Xingyu, Li, Guoliang, Wu, Peng. 2020. HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer. In Journal of genetics and genomics = Yi chuan xue bao, 47, 437-450. doi:10.1016/j.jgg.2020.05.006. https://pubmed.ncbi.nlm.nih.gov/33023834/
5. Ning, Yichong, Wang, Chunqing, Liu, Xin, Zhou, Jianlin, Zhou, Chang. 2019. CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression. In Journal of experimental & clinical cancer research : CR, 38, 131. doi:10.1186/s13046-019-1137-8. https://pubmed.ncbi.nlm.nih.gov/30885251/
6. Zhi, Wenhua, Wei, Ye, Lazare, Cordelle, Cao, Canhui, Wu, Peng. 2022. HPV-CCDC106 integration promotes cervical cancer progression by facilitating the high expression of CCDC106 after HPV E6 splicing. In Journal of medical virology, 95, e28009. doi:10.1002/jmv.28009. https://pubmed.ncbi.nlm.nih.gov/35854676/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest