C57BL/6JCya-Usp36em1/Cya
Common Name:
Usp36-KO
Product ID:
S-KO-18222
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Usp36-KO
Strain ID
KOCMP-72344-Usp36-B6J-VB
Gene Name
Product ID
S-KO-18222
Gene Alias
2700002L06Rik; mKIAA1453
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
11
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Usp36em1/Cya mice (Catalog S-KO-18222) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000092382
NCBI RefSeq
NM_001033528
Target Region
Exon 5~6
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
Usp36, a member of the USP family of deubiquitinating enzymes, plays a crucial role in the balance between ubiquitination and deubiquitination, hydrolyzing and removing ubiquitin chains from target proteins. It is involved in various cellular events such as gene transcription regulation, cell cycle regulation, and immune responses, which are essential for maintaining cellular homeostasis [8].
In cancer, Usp36 has been implicated in promoting tumorigenesis and drug resistance. In breast cancer, it deubiquitinates and stabilizes ERα, promoting tumorigenesis and tamoxifen resistance [2]. In colorectal cancer, Usp36 inhibits apoptosis by deubiquitinating cIAP1 and survivin, and promotes cancer progression by inhibiting the p53 signaling pathway via stabilizing RBM28 [3,4]. In glioblastoma, it deubiquitinates and stabilizes ALKBH5, promoting tumorigenesis and affecting drug sensitivity [5]. In esophageal squamous carcinoma, USP36 stabilizes YAP to facilitate cancer progression [6]. Also, in non-small cell lung cancer, a germline USP36 mutation confers resistance to EGFR-TKIs by upregulating MLLT3 expression [10]. Additionally, in doxorubicin-induced cardiomyopathy, Dox promotes disease progression by activating USP36-mediated PARP1 deubiquitination [7]. In ribosome biogenesis, USP36 acts as a SUMO ligase to promote EXOSC10 SUMOylation, which is critical for the RNA exosome function in rRNA processing [9]. In solid tumors, ribotoxic stress activates the JNK-USP36 signaling to stabilize Snail1 in the nucleolus, facilitating ribosome biogenesis and tumor cell survival, and contributing to resistance to the ribosome inhibitor homoharringtonine (HHT) [1].
In conclusion, Usp36 is a multifunctional deubiquitinating enzyme with significant implications in cancer and other diseases. Studies using in vivo models such as xenograft models in breast cancer [2] and intracranial tumor growth assays in glioblastoma [5] have helped reveal its role in promoting tumorigenesis and drug resistance. These findings suggest that targeting Usp36 could be a potential therapeutic strategy for treating related diseases.
References:
1. Qin, Kewei, Yu, Shuhan, Liu, Yang, Xiao, Zhi-Xiong Jim, Yi, Yong. 2023. USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress. In Nature communications, 14, 6473. doi:10.1038/s41467-023-42257-8. https://pubmed.ncbi.nlm.nih.gov/37833415/
2. Zhuang, Ting, Zhang, Shuqing, Liu, Dongyi, Zhu, Jian, Yang, Huijie. 2024. USP36 promotes tumorigenesis and tamoxifen resistance in breast cancer by deubiquitinating and stabilizing ERα. In Journal of experimental & clinical cancer research : CR, 43, 249. doi:10.1186/s13046-024-03160-2. https://pubmed.ncbi.nlm.nih.gov/39215346/
3. Gao, Bao, Qiao, Yuan, Zhu, Shan, Liu, Yong-Jun, Chen, Jingtao. 2024. USP36 inhibits apoptosis by deubiquitinating cIAP1 and survivin in colorectal cancer cells. In The Journal of biological chemistry, 300, 107463. doi:10.1016/j.jbc.2024.107463. https://pubmed.ncbi.nlm.nih.gov/38876304/
4. Xu, Hengjie, Wang, Tuo, Nie, Hongxu, Feng, Yifei, Sun, Yueming. 2024. USP36 promotes colorectal cancer progression through inhibition of p53 signaling pathway via stabilizing RBM28. In Oncogene, 43, 3442-3455. doi:10.1038/s41388-024-03178-y. https://pubmed.ncbi.nlm.nih.gov/39343961/
5. Chang, Guoqiang, Xie, Gloria S, Ma, Li, Li, Linlin, Richard, Hope T. . USP36 promotes tumorigenesis and drug sensitivity of glioblastoma by deubiquitinating and stabilizing ALKBH5. In Neuro-oncology, 25, 841-853. doi:10.1093/neuonc/noac238. https://pubmed.ncbi.nlm.nih.gov/36239338/
6. Zhang, Wenhao, Luo, Junwen, Xiao, Zhaohua, Zhu, Jian, Zhao, Xiaogang. 2022. USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP. In Cell death & disease, 13, 1021. doi:10.1038/s41419-022-05474-5. https://pubmed.ncbi.nlm.nih.gov/36470870/
7. Wang, Dongchen, Jiang, Zihao, Kan, Junyan, Zhu, Linlin, Gu, Yue. 2024. USP36-mediated PARP1 deubiquitination in doxorubicin-induced cardiomyopathy. In Cellular signalling, 117, 111070. doi:10.1016/j.cellsig.2024.111070. https://pubmed.ncbi.nlm.nih.gov/38307305/
8. Niu, Meng-Yao, Liu, Yan-Jun, Shi, Jin-Jin, Yang, Guan-Jun, Chen, Jiong. 2024. The Emerging Role of Ubiquitin-Specific Protease 36 (USP36) in Cancer and Beyond. In Biomolecules, 14, . doi:10.3390/biom14050572. https://pubmed.ncbi.nlm.nih.gov/38785979/
9. Chen, Yingxiao, Li, Yanping, Dai, Roselyn S, Sun, Xiao-Xin, Dai, Mu-Shui. . The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing. In Nucleic acids research, 51, 3934-3949. doi:10.1093/nar/gkad140. https://pubmed.ncbi.nlm.nih.gov/36912080/
10. Guan, Shaoxing, Chen, Xi, Wei, Yuru, Wang, Xueding, Zhang, Li. . Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer. In Clinical cancer research : an official journal of the American Association for Cancer Research, 30, 1382-1396. doi:10.1158/1078-0432.CCR-23-2357. https://pubmed.ncbi.nlm.nih.gov/38261467/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen