C57BL/6JCya-Lysmd4em1/Cya
Common Name
Lysmd4-KO
Product ID
S-KO-19204
Backgroud
C57BL/6JCya
Strain ID
KOCMP-75099-Lysmd4-B6J-VB
When using this mouse strain in a publication, please cite “Lysmd4-KO Mouse (Catalog S-KO-19204) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Lysmd4-KO
Strain ID
KOCMP-75099-Lysmd4-B6J-VB
Gene Name
Product ID
S-KO-19204
Gene Alias
4930506D23Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000058771
NCBI RefSeq
NM_175215
Target Region
Exon 2
Size of Effective Region
~1.2 kb
Overview of Gene Research
Check the content of the review LYSMD4, information about its common aliases is not provided in the given references. Its essential functions, associated pathways, and overall biological importance are yet to be comprehensively defined. However, genetic models could potentially be valuable for further exploring its roles.
In genetic studies, LYSMD4 has been associated with several conditions. In a multi-ethnic whole-genome sequencing study, LYSMD4 was identified among loci demonstrating sex-specific associations with bone mineral density (BMD), specifically in men [2]. In addition, in transcriptome-wide association studies (TWAS) for Alzheimer's disease (AD), LYSMD4 was identified as one of five novel gene associations in cortical brain tissue, suggesting its possible involvement in the genetic architecture underlying AD risk [1,4]. Also, in a case of Weill-Marchesani syndrome 4, a maternal submicroscopic deletion on chromosome 15q26.3 affected the sequences of LYSMD4 along with ADAMTS17 and CERS3 [3].
In conclusion, LYSMD4 appears to be associated with bone mineral density in a sex-specific manner in men, may play a role in the genetic risk of Alzheimer's disease, and is affected in a chromosomal deletion related to Weill-Marchesani syndrome 4. The study of LYSMD4 through genetic models could potentially provide more insights into these disease-related biological processes.
References：
1. Mews, Makaela A, Naj, Adam C, Griswold, Anthony J, Below, Jennifer E, Bush, William S. 2024. Brain and Blood Transcriptome-Wide Association Studies Identify Five Novel Genes Associated with Alzheimer's Disease. In medRxiv : the preprint server for health sciences, , . doi:10.1101/2024.04.17.24305737. https://pubmed.ncbi.nlm.nih.gov/38699333/
2. Greenbaum, Jonathan, Su, Kuan-Jui, Zhang, Xiao, Shen, Hui, Deng, Hong-Wen. . A multiethnic whole genome sequencing study to identify novel loci for bone mineral density. In Human molecular genetics, 31, 1067-1081. doi:10.1093/hmg/ddab305. https://pubmed.ncbi.nlm.nih.gov/34673960/
3. Yu, Xiaowei, Kline, Brad, Han, Ying, Fan, Zhigang, Shi, Yan. 2022. Weill-Marchesani syndrome 4 caused by compound heterozygosity of a maternal submicroscopic deletion and a paternal nonsense variant in the ADAMTS17 gene: A case report. In American journal of ophthalmology case reports, 26, 101541. doi:10.1016/j.ajoc.2022.101541. https://pubmed.ncbi.nlm.nih.gov/35496767/
4. Mews, Makaela A, Naj, Adam C, Griswold, Anthony J, Below, Jennifer E, Bush, William S. 2025. Brain and blood transcriptome-wide association studies identify five novel genes associated with Alzheimer's disease. In Journal of Alzheimer's disease : JAD, 105, 228-244. doi:10.1177/13872877251326288. https://pubmed.ncbi.nlm.nih.gov/40111921/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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