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Animal Models
C57BL/6JCya-Fxnem1/Cya
Fxn is located on chromosome 19 of mice. Nuclease Technology will be used to design sgRNA; Fxn knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Rfx5em1/Cya
Rfx5 is located on chromosome 3 of mice. Nuclease Technology was used to design sgRNA; Rfx5 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Rfx8em1/Cya
Rfx8 is located on chromosome 1 of mice. Nuclease Technology was used to design sgRNA; Rfx8 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Rfx8em1/Cya
Rfx8 is located on chromosome 1 of mice. Nuclease Technology was used to design sgRNA; Rfx8 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Rfx3em1/Cya
Rfx3 is located on chromosome 19 of mice. Nuclease Technology was used to design sgRNA; Rfx3 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Rfx4em1/Cya
Rfx4 is located on chromosome 10 of mice. Nuclease Technology will be used to design sgRNA; Rfx4 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Rfx2em1/Cya
Rfx2 is located on chromosome 17 of mice. Nuclease Technology will be used to design sgRNA; Rfx2 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Rfx1em1/Cya
Rfx1 is located on chromosome 8 of mice. Nuclease Technology will be used to design sgRNA; Rfx1 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Nfx1em1/Cya
Nfx1 is located on chromosome 4 of mice. Nuclease Technology will be used to design sgRNA; Nfx1 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Rfx7em1/Cya
Rfx7 is located on chromosome 9 of mice. Nuclease Technology will be used to design sgRNA; Rfx7 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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Global Antibody Drug Industry Development BlueBook (Frost & Sullivan)
Key Insights
The industry is undergoing a rapid transformation driven by next-generation modalities, globalized markets, and upstream technological innovations.
  • Market Structural Shift: Monoclonal antibodies drive steady growth, but ADCs and bispecifics are rapidly accelerating, reshaping the market with higher-value innovations.
  • Chinese Market Globalization: China is actively expanding globally, evidenced by a surge in high-value cross-border license-out deals.
  • Technology-Driven Efficiency: Advanced discovery engines—exemplified by Cyagen's HUGO-Ab platform and AI algorithms—are streamlining candidate screening, optimizing molecular design, and localizing the upstream supply chain.
  • Oncology-Focused Innovation: R&D pipelines remain heavily concentrated on high-incidence malignancies like non-small cell lung cancer, utilizing complex modalities to combat clinical resistance.
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