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Animal Models
C57BL/6JCya-Xdhem1/Cya
Xdh is located on chromosome 17 of mice. Nuclease Technology will be used to design sgRNA; Xdh knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Mxd4em1/Cya
Mxd4 is located on chromosome 5 of mice. Nuclease Technology was used to design sgRNA; Mxd4 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Naxdem1/Cya
Naxd is located on chromosome 8 of mice. Nuclease Technology was used to design sgRNA; Naxd knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Mxd1em1/Cya
Mxd1 is located on chromosome 6 of mice. Nuclease Technology will be used to design sgRNA; Mxd1 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Pxdnem1/Cya
Pxdn is located on chromosome 12 of mice. Nuclease Technology was used to design sgRNA; Pxdn knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Exd1em1/Cya
Exd1 is located on chromosome 2 of mice. Nuclease Technology was used to design sgRNA; Exd1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Exd2em1/Cya
Exd2 is located on chromosome 12 of mice. Nuclease Technology will be used to design sgRNA; Exd2 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6NCya-Exd2em1/Cya
Exd2 is located on chromosome 12 of mice. Nuclease Technology was used to design sgRNA; Exd2 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Zxdcem1/Cya
Zxdc is located on chromosome 6 of mice. Nuclease Technology will be used to design sgRNA; Zxdc knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Kxd1em1/Cya
Kxd1 is located on chromosome 8 of mice. Nuclease Technology will be used to design sgRNA; Kxd1 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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Global Antibody Drug Industry Development BlueBook (Frost & Sullivan)
Key Insights
The industry is undergoing a rapid transformation driven by next-generation modalities, globalized markets, and upstream technological innovations.
  • Market Structural Shift: Monoclonal antibodies drive steady growth, but ADCs and bispecifics are rapidly accelerating, reshaping the market with higher-value innovations.
  • Chinese Market Globalization: China is actively expanding globally, evidenced by a surge in high-value cross-border license-out deals.
  • Technology-Driven Efficiency: Advanced discovery engines—exemplified by Cyagen's HUGO-Ab platform and AI algorithms—are streamlining candidate screening, optimizing molecular design, and localizing the upstream supply chain.
  • Oncology-Focused Innovation: R&D pipelines remain heavily concentrated on high-incidence malignancies like non-small cell lung cancer, utilizing complex modalities to combat clinical resistance.
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