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Animal Models
C57BL/6JCya-Crpem1flox/Cya
Crp is located on chromosome 1 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Crp conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Acrem1flox/Cya
Acr is located on chromosome 15 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Acr conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Acrem1/Cya
Acr is located on chromosome 15 of mice. Nuclease Technology was used to design sgRNA; Acr knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Crpem1/Cya
Crp is located on chromosome 1 of mice. Nuclease Technology was used to design sgRNA; Crp knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Crhem1/Cya
Crh is located on chromosome 3 of mice. Nuclease Technology was used to design sgRNA; Crh knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Crxem1/Cya
Crx is located on chromosome 7 of mice. Nuclease Technology will be used to design sgRNA; Crx knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Crhem1/Cya
Crh is located on chromosome 3 of mice. Nuclease Technology was used to design sgRNA; Crh knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6NCya-Crpem1flox/Cya
Crp is located on chromosome 1 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Crp conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Acrem1/Cya
Acr is located on chromosome 15 of mice. Nuclease Technology will be used to design sgRNA; Acr knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Cr2em1/Cya
Cr2 is located on chromosome 1 of mice. Nuclease Technology will be used to design sgRNA; Cr2 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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Global Antibody Drug Industry Development BlueBook (Frost & Sullivan)
Key Insights
The industry is undergoing a rapid transformation driven by next-generation modalities, globalized markets, and upstream technological innovations.
  • Market Structural Shift: Monoclonal antibodies drive steady growth, but ADCs and bispecifics are rapidly accelerating, reshaping the market with higher-value innovations.
  • Chinese Market Globalization: China is actively expanding globally, evidenced by a surge in high-value cross-border license-out deals.
  • Technology-Driven Efficiency: Advanced discovery engines—exemplified by Cyagen's HUGO-Ab platform and AI algorithms—are streamlining candidate screening, optimizing molecular design, and localizing the upstream supply chain.
  • Oncology-Focused Innovation: R&D pipelines remain heavily concentrated on high-incidence malignancies like non-small cell lung cancer, utilizing complex modalities to combat clinical resistance.
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