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Animal Models
C57BL/6JCya-Polqem1flox/Cya
Polq is located on chromosome 16 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Polq conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Sfpqem1flox/Cya
Sfpq is located on chromosome 4 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Sfpq conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Helqem1flox/Cya
Helq is located on chromosome 5 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Helq conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Gnaqem1flox/Cya
Gnaq is located on chromosome 19 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Gnaq conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Cpqem1flox/Cya
Cpq is located on chromosome 15 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Cpq conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Ccnqem1flox/Cya
Ccnq is located on chromosome 11 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Ccnq conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Colqem1flox/Cya
Colq is located on chromosome 14 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Colq conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Irgqem1flox/Cya
Irgq is located on chromosome 7 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Irgq conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Pigqem1flox/Cya
Pigq is located on chromosome 17 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Pigq conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Dgkqem1flox/Cya
Dgkq is located on chromosome 5 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Dgkq conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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Global Antibody Drug Industry Development BlueBook (Frost & Sullivan)
Key Insights
The industry is undergoing a rapid transformation driven by next-generation modalities, globalized markets, and upstream technological innovations.
  • Market Structural Shift: Monoclonal antibodies drive steady growth, but ADCs and bispecifics are rapidly accelerating, reshaping the market with higher-value innovations.
  • Chinese Market Globalization: China is actively expanding globally, evidenced by a surge in high-value cross-border license-out deals.
  • Technology-Driven Efficiency: Advanced discovery engines—exemplified by Cyagen's HUGO-Ab platform and AI algorithms—are streamlining candidate screening, optimizing molecular design, and localizing the upstream supply chain.
  • Oncology-Focused Innovation: R&D pipelines remain heavily concentrated on high-incidence malignancies like non-small cell lung cancer, utilizing complex modalities to combat clinical resistance.
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