C57BL/6JCya-Copg1em1flox/Cya
Common Name
Copg1-flox
Product ID
S-CKO-11698
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-54161-Copg1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Copg1-flox Mouse (Catalog S-CKO-11698) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Copg1-flox
Strain ID
CKOCMP-54161-Copg1-B6J-VA
Gene Name
Product ID
S-CKO-11698
Gene Alias
Copg, D6Wsu16e, D6Ertd71e
Background
C57BL/6JCya
Gene Full Name
coatomer protein complex, subunit gamma 1
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 6 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000113607
NCBI Transcript ID
NM_017477
Target Region
Exon 2~5
Size of Effective Region
~2.2 kb
Overview of Gene Research
Copg1, a subunit of the coatomer complex I (COPI), is involved in mediating retrograde vesicular trafficking from Golgi to the endoplasmic reticulum (ER) and within Golgi compartments [1]. COPI is crucial for maintaining the proper organization and function of the Golgi apparatus and ER, which are key cellular components involved in protein processing and transport.
Genetic deletion of COPG1 in in vitro models leads to aberrant activation of the STING pathway and type I IFN activation, suggesting its role in innate immune regulation [1]. In a proteome-wide association study, COPG1 was associated with an increased risk of breast cancer, indicating its potential involvement in cancer-related biological processes [2]. A new severe congenital neutropenia syndrome, caused by autosomal recessive COPZ1 mutations, showed that these mutations affected the interaction with COPG1 and led to impaired granulocytic differentiation, highlighting COPG1's importance in hematopoiesis [3].
In summary, Copg1 plays essential roles in vesicular trafficking, innate immune response, hematopoiesis, and may be associated with breast cancer development. Studies using genetic deletion in in vitro models have been instrumental in revealing these functions, providing insights into the biological processes and disease conditions related to Copg1.
References：
1. Steiner, Annemarie, Hrovat-Schaale, Katja, Prigione, Ignazia, Davidson, Sophia, Masters, Seth L. 2022. Deficiency in coatomer complex I causes aberrant activation of STING signalling. In Nature communications, 13, 2321. doi:10.1038/s41467-022-29946-6. https://pubmed.ncbi.nlm.nih.gov/35484149/
2. Zhao, Tianying, Xu, Shuai, Ping, Jie, Zheng, Wei, Long, Jirong. 2024. A proteome-wide association study identifies putative causal proteins for breast cancer risk. In British journal of cancer, 131, 1796-1804. doi:10.1038/s41416-024-02879-1. https://pubmed.ncbi.nlm.nih.gov/39468330/
3. Borbaran Bravo, Natalia, Deordieva, Ekaterina, Doll, Larissa, Klimiankou, Maksim, Skokowa, Julia. . A new severe congenital neutropenia syndrome associated with autosomal recessive COPZ1 mutations. In Blood, 145, 2317-2335. doi:10.1182/blood.2023022576. https://pubmed.ncbi.nlm.nih.gov/39642330/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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