C57BL/6JCya-Tlr6em1/Cya
Common Name
Tlr6-KO
Product ID
S-KO-17564
Backgroud
C57BL/6JCya
Strain ID
KOCMP-21899-Tlr6-B6J-VA
Status
When using this mouse strain in a publication, please cite “Tlr6-KO Mouse (Catalog S-KO-17564) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Tlr6-KO
Strain ID
KOCMP-21899-Tlr6-B6J-VA
Gene Name
Product ID
S-KO-17564
Gene Alias
--
Background
C57BL/6JCya
Gene Full Name
toll-like receptor 6
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 5 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000239485
NCBI Transcript ID
NM_011604
Target Region
Exon 2
Size of Effective Region
~2.7 kb
Overview of Gene Research
Tlr6, a member of the Toll-like receptor family, is a type-I transmembrane receptor with an extracellular leucine-rich repeat (LRR) domain and a cytoplasmic Toll/IL-1 receptor-like region [6]. It plays a crucial role in the innate immune response by recognizing conserved microbial products, such as peptidoglycan from Gram-positive bacteria. TLR6 often forms heterodimers with TLR2 to activate the signaling cascade, leading to the activation of multiple inflammatory genes and thus regulating both innate and adaptive immunity [3].
In terms of disease-related findings, the TLR2/TLR6 ligand FSL-1 was shown to mitigate radiation-induced hematopoietic injury in mice and non-human primates, promoting hematopoietic progenitor cell proliferation and red blood cell development [1]. High TLR6 expression status in locally advanced thoracic esophageal squamous cell carcinoma patients predicted a more favorable prognosis after esophagectomy, and peptidoglycan (recognized by TLR6) inhibited the cell proliferation activity of esophageal squamous cell carcinoma lines [2]. In sepsis-induced ARDS, miR-34a-5p may promote TLR6 to heighten inflammation [4]. Also, sustained exposure to Helicobacter pylori desensitized TLR6, inducing immune tolerance, and restoration of TLR6 reduced H. pylori colonization in gerbils [5].
In conclusion, Tlr6 is essential for innate immunity and has significant implications in various disease conditions. Studies using animal models, like the non-human primates and gerbils in the above-mentioned research, have revealed its role in radiation-induced hematopoietic injury, cancer prognosis, and infectious disease-related immune responses. Understanding Tlr6 function provides potential therapeutic targets for these diseases.
References：
1. Brickey, W June, Caudell, David L, Macintyre, Andrew N, Cline, J Mark, Ting, Jenny P Y. 2023. The TLR2/TLR6 ligand FSL-1 mitigates radiation-induced hematopoietic injury in mice and nonhuman primates. In Proceedings of the National Academy of Sciences of the United States of America, 120, e2122178120. doi:10.1073/pnas.2122178120. https://pubmed.ncbi.nlm.nih.gov/38051771/
2. Sato, Yusuke, Wakita, Akiyuki, Maeda, Eri, Nomura, Kyoko, Minamiya, Yoshihiro. 2023. High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma. In Current oncology (Toronto, Ont.), 30, 4724-4735. doi:10.3390/curroncol30050356. https://pubmed.ncbi.nlm.nih.gov/37232814/
3. Noreen, Mamoona, Arshad, Muhammad. . Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility. In Immunologic research, 62, 234-52. doi:10.1007/s12026-015-8640-6. https://pubmed.ncbi.nlm.nih.gov/25784622/
4. Khan, Mohd Junaid, Singh, Prithvi, Jha, Prakash, Singh, Indrakant Kumar, Syed, Mansoor Ali. 2023. Investigating the link between miR-34a-5p and TLR6 signaling in sepsis-induced ARDS. In 3 Biotech, 13, 282. doi:10.1007/s13205-023-03700-1. https://pubmed.ncbi.nlm.nih.gov/37496978/
5. Zhang, Xiulin, He, Yang, Zhang, Xiaolu, Chen, Zhenwen, Li, Changlong. 2024. Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6. In Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 27, 324-342. doi:10.1007/s10120-023-01461-7. https://pubmed.ncbi.nlm.nih.gov/38310631/
6. Takeuchi, O, Kawai, T, Sanjo, H, Takeda, K, Akira, S. . TLR6: A novel member of an expanding toll-like receptor family. In Gene, 231, 59-65. doi:. https://pubmed.ncbi.nlm.nih.gov/10231569/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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