C57BL/6JCya-Dpp3em1/Cya
Common Name
Dpp3-KO
Product ID
S-KO-17752
Backgroud
C57BL/6JCya
Strain ID
KOCMP-75221-Dpp3-B6J-VB
Status
When using this mouse strain in a publication, please cite “Dpp3-KO Mouse (Catalog S-KO-17752) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Dpp3-KO
Strain ID
KOCMP-75221-Dpp3-B6J-VB
Gene Name
Product ID
S-KO-17752
Gene Alias
DPP III, 4930533O14Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19 (Mouse)
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Transcript ID
ENSMUST00000025851
NCBI Transcript ID
NM_133803
Target Region
Exon 6
Size of Effective Region
~0.1 kb
Overview of Gene Research
Dpp3, also known as dipeptidyl peptidase 3, is the first zinc-dependent peptidase among DPPs. It has a unique HEXXGH catalytic sequence and is mainly located in the cytoplasm, associated with the degradation of oligopeptides with 4-10 amino acid residues. It participates in multiple cellular activities and pathophysiological mechanisms, including interacting with the renin-angiotensin system to regulate blood pressure, and is involved in pain signaling, inflammation, and oxidative stress [1].
In cardiovascular diseases, Dpp3 is used as a biomarker for poor prognosis in patients. For example, in cardiogenic shock patients, the plasma concentration of Dpp3 is closely related to mortality, and higher levels in ventilated patients may predict disease progression [1,6]. In cancer, Dpp3 is upregulated in breast, esophageal, and colorectal cancers. In breast cancer, it promotes tumorigenesis by stabilizing FASN and promoting lipid synthesis [2]. In esophageal carcinoma, its depletion reduces cell proliferation, migration, and tumor growth in a xenograft model [3]. In colorectal cancer, downregulation of Dpp3 inhibits cell proliferation, migration, and promotes apoptosis, and Dpp3 may act through targeting CDK1 [4]. In esophageal squamous cell carcinoma, knockdown of Dpp3 leads to reduced proliferation, increased apoptosis, and inhibited migration, along with down-regulation of the NRF2 pathway and increased sensitivity to oxidative stress and chemotherapy [5].
In conclusion, Dpp3 plays a significant role in cardiovascular diseases as a biomarker and potentially as a therapeutic target. In cancer, it promotes tumor development and progression in multiple types of malignancies. The study of Dpp3 in gene-knockout or conditional-knockout models, although not directly mentioned in the references in terms of these models, would further clarify its exact mechanisms in these biological processes and diseases, providing a better understanding of its biological functions and potential for treatment strategies.
References：
1. Ye, Peng, Duan, Wei, Leng, Yue-Qi, Tan, Xing, Wang, Wei-Zhong. 2022. DPP3: From biomarker to therapeutic target of cardiovascular diseases. In Frontiers in cardiovascular medicine, 9, 974035. doi:10.3389/fcvm.2022.974035. https://pubmed.ncbi.nlm.nih.gov/36312232/
2. Fu, Xiaoyu, Li, Xu, Wang, Weixing, Li, Juanjuan. . DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis. In Acta biochimica et biophysica Sinica, 56, 805-818. doi:10.3724/abbs.2024054. https://pubmed.ncbi.nlm.nih.gov/38655619/
3. Liu, Jing-Kun, Abudula, Abulizi, Yang, Hai-Tao, Tulahong, Aisiker, Eli, Maynur. 2022. DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma. In Oncology reports, 49, . doi:10.3892/or.2022.8446. https://pubmed.ncbi.nlm.nih.gov/36382663/
4. Tong, Yixin, Huang, Yuan, Zhang, Yuchao, Xia, Zhongsheng, Lai, Dongming. 2021. DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration. In Cell death & disease, 12, 529. doi:10.1038/s41419-021-03796-4. https://pubmed.ncbi.nlm.nih.gov/34023852/
5. Arora, Mohit, Kumari, Sarita, Kadian, Lokesh, Chopra, Anita, Chauhan, Shyam S. . Involvement of DPP3 in modulating oncological features and oxidative stress response in esophageal squamous cell carcinoma. In Bioscience reports, 43, . doi:10.1042/BSR20222472. https://pubmed.ncbi.nlm.nih.gov/37531267/
6. Innelli, Pasquale, Lopizzo, Teresa, Paternò, Giovanni, Pittella, Giuseppe, Paternoster, Gianluca. 2023. Dipeptidyl Amino-Peptidase 3 (DPP3) as an Early Marker of Severity in a Patient Population with Cardiogenic Shock. In Diagnostics (Basel, Switzerland), 13, . doi:10.3390/diagnostics13071350. https://pubmed.ncbi.nlm.nih.gov/37046568/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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