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Video
Comparing Mouse and Rat Models for Research
Mar 12, 2021
As researchers seek the most accurate animal models for in vivo experiments, the availability of gene-editing technologies for developing both mouse and rat models has created more options than ever before. Murine genomes share great similarity with the human genome, which has made them fantastic models for a wide range human disease research. Read More >
Research Trend
Case Studies in Gene Therapy - Applications of Accurate Mouse Models
Mar 08, 2021
Gene therapy introduces a modified gene into diseased cells to treat a genetic-based disease. The new gene usually contains a functioning gene to correct the effects of a disease-causing mutation, which may be either spontaneous or inherited. In the past few decades, gene therapy has made significant progress in the treatment of genetic diseases. In practice, scientists apply genomic and proteomic methods to identify the disease-causing gene, subsequently verifying the target gene with in vitro and in vivo experiments. With this methodology, scientists have published many high-impact gene therapy research articles. Read More >
Newsletter
Weekly Gene
Pathogenic Genes of Rare Disease - SMN1 in Spinal Muscular Atrophy Research
Mar 05, 2021
cord, which affects the central nervous system, peripheral nervous system, and voluntary muscle movement. The primary pathogenic gene of spinal muscular atrophy is the survival of motor neuron 1 (SMN1) gene, mutations of which cause a deficiency of SMN motor neuron protein – ultimately resulting in Chromosome 5 SMA, the most common form of SMA. Read More >
Newsletter
Breaking News
Rare Disease Day 2021 – Achieving Equity
Feb 26, 2021
With over 300 million people worldwide living with a rare disease, Rare Disease Day aims to raise awareness of what it means to be rare. On the last day of February each year, the Rare Disease community comes together to work toward more equitable access to diagnosis, treatment, care, and social opportunity for people with a rare disease. Read More >
Newsletter
Weekly Gene
【Gene of the Week】Metabolism & Cardiovascular Diseases - SIRT3
Feb 26, 2021
The SIRT3 gene plays an important role in the pathogenesis of metabolic, cardiovascular, and neurodegenerative diseases. In this article, we review the functionality of SIRT3 and explore its role in metabolism & cardiovascular disease studies - bringing together insights to SIRT3 gene research developments to provide inspiration for your scientific innovation. Read More >
Newsletter
Video
The PiggyBAC Transposon - Generating Transgenic Mice with Consistent Expression
Feb 23, 2021
In most experiments, scientists will try to minimize the number of independent variables so as not to confuse the results of an experiment. Due to the varying level of gene expression achieved by traditional pronuclear injection (PNI), using the offspring from a transgenic mouse created via PNI may not be the best option. Read More >
Weekly Gene
[Gene of the Week] The Next Generation Target for Immunotherapy - CD134 (TNFRSF4)
Feb 18, 2021
Immune checkpoint proteins (ICP) are a group of signaling molecules possessed by immune cells that can regulate and control the persistence of immune response. The immune checkpoint signaling pathway consists of inhibitory and stimulatory pathways that maintain self-tolerance and assist with the immune response. Read More >
Research Trend
Newsletter
COVID-19
Beyond Alzheimer’s Disease – Implications of APOE in Viral Pathology
Feb 09, 2021
The APOE gene - which encodes Apolipoprotein E – has been extensively studied due to its biological relevance to a range of neurological and cardiovascular diseases, including Alzheimer’s Disease (AD). In addition to the roles APOE plays in developmental diseases such as AD, additional studies have shown APOE to be implicated in the host response to a range of infectious pathogens, including herpes simplex virus type I (HSV1) and hepatitis C virus (HCV). Read More >
One-Minute Survey: Cyagen Knockout Catalog Models Improve our offerings and receive $2,000 credit!
Feb 04, 2021
Given your interest in and/or purchase from the Cyagen Knockout Catalog Models repository, we would appreciate your participation in a one-minute survey. Your feedback will be used to improve our catalog offerings. Read More >
Newsletter
Video
Pronuclear Injection-based Transgenic Mouse Model Generation
Feb 02, 2021
Transgenic mice are important tools for scientists researching heritable traits and diseases in human populations. In traditional transgenics, the human gene (packaged in a transgenic construct) can be added to the mouse genome with a simple pronuclear injection into the male pronucleus. Read More >