hF11
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
hF11
Product ID
C001272
Gene Name
Background
C57BL/6NCya
Gene Alias
FXI; PTA
Classification
Cytokine Humanized Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
4
Document
Note: When using this mouse strain in a publication, please cite “hF11 mice (Catalog C001272) were purchased from Cyagen.”
Strain Description
This strain is a humanized model of F11 in which the CDS of human F11 (hF11) is expressed under the regulation of the mouse endogenous F11 gene promoter, and the expression of the mouse F11 gene is disrupted to reduce cross-reactivity. This model can be used for in vivo efficacy assessment and analysis of diseases associated with human F11, and homozygous hF11 mice are viable and fertile.
Application Area
Research on Rosenthal syndrome
Research on the intrinsic pathway of blood coagulation
Validation Data