Metabolic Disease Models

Alongside the aging of society and the prevalence of obesity, the incidence of metabolic diseases is increasing yearly - which is a serious threat to human health. The most common metabolic diseases include obesity, type 2 diabetes caused by insulin resistance, and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH).

Cyagen can provide you with a variety of metabolic disease models along with phenotype analysis services – delivering reliable and expedient data reporting for your project.

Obesity Mouse Models

The diet-induced obesity (DIO) model recapitulates metabolic factors implicated in human obesity, which has led to its use in studying the relationship between diet, genes, and other factors in the developmental processes of obesity, diabetes, and related metabolic disorders.

Obesity is a metabolic disorder affected by numerous factors such as diet, environment, genetics, and more - it is often the main cause of many chronic diseases. Animal models are essential tools for further understanding of the pathogenesis of obesity and exploring effective treatment methods. At present, animal models of obesity are mainly divided into four categories: diet-induced obesity, hypothalamic obesity, obesity caused by endocrine disorders, and genetic contributors.

Cyagen can provide you with various obesity mouse models and phenotype analysis services - please contact us for a custom project quote.

Diet-induced obesity (DIO) Model
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Diabetes Mellitus (DM) Mouse Models

Diabetes mellitus (DM) animal models play an important role in the study of diabetes mellitus and are generally categorized into spontaneous, induced, and genetically engineered models.

Diabetes mellitus (DM), commonly known as diabetes, is a syndrome characterized by chronic hyperglycemia and is caused by genetic, environmental, immune, and other factors. Diabetes has become the third leading chronic disease among the population, following cancer and cardiovascular disease (CVD). The American Diabetes Association (ADA) has divided diabetes into four types: type I diabetes (T1DM), type II diabetes (T2DM), other special diabetes, and gestational diabetes.

Cyagen can provide you with various obesity and diabetes mellitus mouse models alongside phenotype analysis services - please contact us for a custom project quote.

a. Type 2 Diabetes Mellitus (T2DM) Mouse Model
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b. Type 1 Diabetes Mellitus (T1DM) Mouse Model
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Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Models

Animal models play an important role in elucidating the pathophysiological mechanisms of non-alcoholic fatty liver disease (NAFLD) and the development of new drugs.

Non-alcoholic fatty liver disease (NAFLD) is a hepatopathy syndrome affecting both adults and children that is characterized by a range of liver conditions affecting people who consume little to no alcohol, including simple fatty liver, steatohepatitis, fatty liver fibrosis, and cirrhosis. NAFLD can progress from simple fatty liver through nonalcoholic steatohepatitis (NASH) to liver fibrosis, and even lead to end-stage liver diseases, such as, liver cirrhosis, hepatocellular carcinoma (HCC), or liver failure.

Preclinical studies require the application of different animal models based on the specific NAFLD phenotype being studied. The preclinical animal models of NAFLD and NASH can be divided into four categories: diet-induced, drug-induced, genetically modified models, and composite (combined) models.

Cyagen can provide you with various Non-alcoholic Fatty Liver Disease (NAFLD) mouse models and phenotype analysis services - please contact us for a custom project quote.

a. Diet-induced Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Model
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b. Chemically Induced Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Model
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c. Non-alcoholic Fatty Liver Disease (NAFLD) Mouse Model (Gene-editing)
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d. Composite (combined) Model - Non-alcoholic Fatty Liver Disease (NAFLD) Model
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Atherosclerosis Mouse Model

Cardiovascular diseases (CVDs) are the leading cause of death across the globe, with Atherosclerosis (AS) serving as the common pathological basis of common cardiovascular and cerebrovascular diseases. Atherosclerosis refers to the thickening and hardening of the arterial wall and narrowing of the vascular lumen, caused by depositions of fat, thrombus, connective tissue, and calcium carbonate in blood vessels. Once these plaques have significantly narrowed or completely blocked the arterial lumen, the tissues and organs which normally receive blood from the artery will develop ischemia or necrosis. The use of animal models of atherosclerosis (AS) is an essential tool to study the occurrence, development, and treatment of cardiovascular diseases. At present, the most common model development techniques include feeding, gavage, injection, mechanical injury, immune injury, and genetic modification.

Cyagen can provide you with various atherosclerosis mouse models and phenotype analysis services - please contact us for a custom project quote.

a. Composite (combined) Model - Atherosclerosis Mouse Model
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b. Atherosclerosis Mouse Model (Gene-editing)
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Pancreatitis Mouse Models

Pancreatitis, a disease that seriously affects the health and quality of life of people, can be classified as either acute or chronic according to its pathological process. Animal models of pancreatitis have played an important role in studying the pathogenesis of pancreatitis and exploring clinical treatment options. There are many methods for preparing pancreatitis animal models, with the injection of sodium taurocholate into the pancreatic duct being a more commonly used method.

Cyagen can provide you with various pancreatitis mouse models and phenotype analysis services - please contact us for a custom project quote.

a. Acute Pancreatitis Mouse Model
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b. Chronic Pancreatitis Mouse Model
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