B6-hTGFB2
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Genotype
Sex
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Basic Information
Model Name
B6-hTGFB2
Product ID
C001792
Gene Name
Background
C57BL/6NCya
Gene Alias
LDS4; G-TSF; TGF-beta2
Classification
Cytokine Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
1
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Note: When using this mouse strain in a publication, please cite “B6-hTGFB2 mice (Catalog C001792) were purchased from Cyagen.”
Strain Description
The B6-hTGFB2 mouse is a humanized model, constructed by replacing the partial coding sequences of mouse Tgfb2 exon 1 with the Kozak-Human TGFB2 CDS-3’UTR of the Human TGFB2-WPRE-BGH pA cassette. B6-hTGFB2 mice can be used for research into the pathogenesis of cardiovascular diseases, fibrosis, cancers, and developmental disorders. They are also useful for the screening, development, and safety evaluation of TGFB2-targeted drugs.
Application Area
TGFB2-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of cardiovascular diseases, cancers, fibrosis, and developmental disorders
Validation Data