Obesity is a chronic, recurrent disorder characterized by excessive body weight and fat accumulation. Beyond its impact on physical appearance, obesity poses significant risks for developing a spectrum of complications, including cardiovascular diseases (CVD), gastrointestinal disorders, type 2 diabetes (T2D), musculoskeletal conditions, respiratory disorders, and other related pathologies. Diet-induced animal models, such as the Diet-Induced Obesity (DIO) mouse model, are designed to mimic human obesity through excessive fat accumulation driven by a high-fat diet. These models are indispensable for preclinical studies assessing the efficacy of therapeutic interventions targeting obesity and its associated complications.

The DIO-B6-M model represents a Diet-Induced Obesity (DIO) mouse model, generated by subjecting male C57BL/6Cya mice to a 60% high-fat diet (HFD). These mice exhibit significant weight gain, elevated random blood glucose levels, increased populations of NK cells and macrophages, and elevated blood lipids and liver function markers. This model is highly valuable for investigating metabolic diseases, such as obesity, diabetes, and inflammation, and for evaluating the efficacy of potential therapeutic agents in preclinical studies. The effectiveness of diet-induced obesity (DIO) modeling can be influenced by various factors including diet, strain, condition, and husbandry practices. Some variability between model batches may occur; please contact us for further information.