B6J-Apoe KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6J-Apoe KO
Product ID
C001507
Gene Name
Background
C57BL/6JCya
Gene Alias
Apo-E
Classification
Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
7
Document
Note: When using this mouse strain in a publication, please cite “B6J-Apoe KO mice (Catalog C001507) were purchased from Cyagen.”
Strain Description
The B6J-Apoe KO mouse is a model of ApoE deficiency. It was generated by gene editing technology to knock out the Apoe gene in mice. ApoE protein synthesis is blocked in these mice, leading to elevated cholesterol levels and spontaneous atherosclerosis. Cholesterol levels and atherosclerosis in mice fed a high-fat diet (HFD) are further exacerbated. The B6J-Apoe KO mice are viable and can be used for research in hypercholesterolemia, atherosclerosis, and Alzheimer's disease.
Application Area
Cardiovascular disease research: Hypercholesterolemia, hyperlipidemia, atherosclerosis, etc.
Body metabolism mechanism research: Fat and cholesterol metabolism
Neurodegenerative disease research: Alzheimer's disease
Validation Data
References
Eur Heart J
Dec, 2023
Myocardial infarction drives trained immunity of monocytes, accelerating atherosclerosis
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Journal of Molecular and Cellular Cardiology
Jun, 2022
ICAM-1-related noncoding RNA accelerates atherosclerosis by amplifying NF-κB signaling
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European Journal of Pharmacology
Oct, 2023
DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE−/− mice via suppressing inflammation, endothelial necroptosis and apoptosis
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