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B6J-Apoe KO
Product ID:
C001507
Background:
C57BL/6JCya
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Strain Description
The B6J-Apoe KO mouse is a model of ApoE deficiency. It was generated by gene editing technology to knock out the Apoe gene in mice. ApoE protein synthesis is blocked in these mice, leading to elevated cholesterol levels and spontaneous atherosclerosis. Cholesterol levels and atherosclerosis in mice fed a high-fat diet (HFD) are further exacerbated. The B6J-Apoe KO mice are viable and can be used for research in hypercholesterolemia, atherosclerosis, and Alzheimer's disease.
Application Area
Area
Cardiovascular disease research: Hypercholesterolemia, hyperlipidemia, atherosclerosis, etc.
Area
Body metabolism mechanism research: Fat and cholesterol metabolism
Area
Neurodegenerative disease research: Alzheimer's disease
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