B6-hCXCR2
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hCXCR2
Product ID
C001626
Gene Name
Background
C57BL/6NCya
Gene Alias
CD182; IL8R2; IL8RA; IL8RB; CMKAR2; WHIMS2; CDw128b
Classification
Tumor Target Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
2
Document
Note: When using this mouse strain in a publication, please cite “B6-hCXCR2 mice (Catalog C001626) were purchased from Cyagen.”
Strain Description
The B6-hCXCR2 mouse is a humanized model constructed using gene editing technology to replace the entire base sequence of the mouse Cxcr2 gene in situ with the corresponding sequence from the human CXCR2 gene. Homozygous B6-hCXCR2 mice are viable and fertile. This model can be used for studying the pathological mechanisms and therapeutic approaches of inflammatory diseases and cancers, and for the development of CXCR2-targeted drugs.
Application Area
CXCR2-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of inflammatory diseases and cancers
Validation Data