B6-hIL23A
Product Type
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Genotype
Sex
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Basic Information
Model Name
B6-hIL23A
Product ID
C001618
Gene Name
Background
C57BL/6NCya
Gene Alias
P19; SGRF; IL-23; IL-23A; IL23P19
Classification
Immune Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
12
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Note: When using this mouse strain in a publication, please cite “B6-hIL23A mice (Catalog C001618) were purchased from Cyagen.”
Strain Description
The B6-hIL23A mouse is a humanized model generated by gene editing, in which the mouse Il23a genomic sequence is replaced with the corresponding sequence from the human IL23A gene, while preserving the endogenous sequence encoding the mouse IL23p19 signal peptide (aa. 1-21). Homozygous B6-hIL23A mice are viable and fertile, and suitable for investigating the pathomechanisms and therapeutic interventions of immune-related diseases and cancer, as well as for screening and developing IL23A-targeted therapeutics, and for preclinical pharmacodynamic and safety evaluations.
Application Area
Screening and development of IL23A-targeted therapeutics, and preclinical pharmacodynamic and safety evaluations
Investigation of pathomechanisms and therapeutic interventions for immune-related diseases
Validation Data