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Case 1 ES cell-mediated Conditional Knock-Out Mice

	Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice. Hepatology (2018) IF=14.079(2018) PMID: 29637572

Case 2 ES cell-mediated Knock-Out Mice

	TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence. Cancer Cell 31:697–710 (2017) IF= 22.844 (2018) PMID: 28486108

Case 3 Nuclease-mediated Knock-Out Mice ( CRISPR )

	Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen. Immunity 47:107–117 (2017) IF= 19.734 (2018) PMID: 28709804