• 'Trimming the fat' with CRISPR
    'Trimming the fat' with CRISPR

    Around 20 million years ago, for unknown reasons, wild pigs lost an important metabolic gene known as uncoupling protein 1 (UCP1). In most mammals this gene plays a major role in generating body heat for thermoregulation, and lack of UCP1 h Read More ›

  • A mammalian half-day clock
    A mammalian half-day clock

    Last month, the Nobel Foundation recognized Jeffrey Hall, Michael Rosbash, and Michael Young "for their discoveries of molecular mechanisms controlling the circadian rhythm". This 24-hour "clock" influences many physiological processes... Read More ›

  • Is ApoE the key to an Alzheimer's cure?
    Is ApoE the key to an Alzheimer's cure?

    Alzheimer’s disease has gained a lot of attention in the past week or so due to new findings about Apolipoprotein E (ApoE) published in Nature1. ApoE genotype has long been known to be a major risk factor for Alzheimer disease... Read More ›

  • Palmitoylation the key to redhead melanoma risk
    Palmitoylation the key to redhead melanoma risk

    Around 100 million people worldwide have red hair due to the variants of the melanocortin-1 receptor (MC1R) gene they carry. In addition to affecting hair color and skin pigmentation, red-hair-color (RHC) MC1R variants also... Read More ›

  • Inducing regeneration
    Inducing regeneration

    In many ways, regeneration is the ‘holy grail’ of medical research. To be able to completely heal from injuries and to regrow lost organs or tissues is a feat that most mammals are generally not capable of... Read More ›

  • Controlling when and where: Conditional and inducible gene expression
    Controlling when and where: Conditional and inducible gene e...

    In the early days of engineered animal models, simple knockout and transgenic mice were used to examine gene function. Researchers began to dissect the roles of individual genes by studying phenotypes of mice lacking or... Read More ›