Il12a KO
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Genotype
Sex
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Basic Information
Model Name
Il12a KO
Product ID
C001213
Gene Name
Background
C57BL/6NCya
Gene Alias
p35; Ll12a; Il-12a; IL-12p35
Classification
Immunodeficient Mouse Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
3
Document
Note: When using this mouse strain in a publication, please cite “Il12a KO mice (Catalog C001213) were purchased from Cyagen.”
Strain Description
This model is an Il12a gene knockout mouse, created using gene-editing technology to knock out the homologous Il12a gene of the human IL12A gene in mice. According to the literature, the deletion of Il12a in this mouse model leads to the loss of the biological effects of IL-12 and IL-35, reduced NK cell responses, altered differentiation of effector T cells, and increased susceptibility to parasitic infections. Additionally, this model cannot exhibit delayed-type hypersensitivity (DTH) reactions induced by the interaction of effector T cells with antigens. The homozygous mice are viable and fertile.
Application Area
Cardiovascular Disease Research
Autoimmune Disease Research
Infectious Disease Research
Immune Cells and Systems Research
Validation Data